May 2013
Advances in the study of the biological function of Daxx
Death domain-associated protein (Daxx) was originally identiï¬ed as a protein that speciï¬cally binds to the death domain of the transmembrane death receptor Fas (also called CD95) in the cytoplasm and potentiates Fas-induced apoptosis. Over expression of Daxx enhances Fas-mediated apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx was found in the nuclears where it localizes to promyelocytic...
May 2013
Antifungal activity of essential oil from Cinnamomum longepaniculatum leaves against three dermatophytes in vitro
The antifungal effects of essential oil from Cinnamomum longepaniculatum leaves were studied with special reference to minimal inhibitory concentration (MIC), minimal fungicidal concentration (MFC), time–kill studies and the mechanism of inhibition at ultrastructural level against Trichophyton mentagrophytes, Microsporum canis and Trichophyton gypseum. Its MICs against three important...
May 2013
Antifungal activity and gas chromatography coupled with mass spectrometry (GC-MS) leaf oil analysis of essential oils extracted from Eucalyptus globulus (Myrtaceae) of north centre region of Morocco
Essential oil from the leaves of Eucalyptus globulus collected in north centre region ofMorocco obtained by hydro-distillation were analyzed by gas chromatography equipped with flame ionisation detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC-MS). To evaluate the antifungal activities of these aromatic extracts, their in vitroantifungal activities...
May 2013
Evaluation of antibacterial effect of monolaurin on Staphylococcus aureus isolated from bovine mastitis
Bovine mastitis is the inflammation of the parenchyma of the mammary glands of cattle associated with microbial infections. The most common bacteria causing bovine mastitis include; Staphylococcus aureus. Monolaurin, a food grade glycerol monoester of lauric acid, has been reported to have the greatest antimicrobial activity of all of the monoglycerides. The aim of this study was to evaluate of antibacterial effect...
May 2013
Efficacy of losartan and combination of losartan plus hydrochlorothiazide for high blood pressure treatment
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May 2013
Lycium barbarum polysaccharides (LBP) extraction technology and its antioxidation activity
This study was carried out to investigate the technology of extracting Lycium barbarumpolysaccharide (LBP) and its antioxidation activity, using orthogonal experimental method to optimize its extraction conditions. Fenton reaction and pyrogallol experimental method were adopted to determine the antioxidation activity of LBP. The three factors investigated in the orthogonal experiment affected the results. Different...
May 2013
Expression of CD44 in osteoarthritis cartilage tissue and its clinical significance
The expression of CD44 in osteoarthritis cartilage tissue and its effect in the generation and development of osteoarthritis (OA) were studied. Forty patients with primary OA who received joint arthroplasty were randomly included in this study as OA group. The normal articular cartilages as control group were obtained following Outerbridge standard from twenty patients who received amputation. The...
May 2013
Efficacy of different medicines used for the treatment of osteoporosis by using dual energy x-ray absorptiometry
Osteoporosis, a skeletal disease and common condition affecting one in three women and one in twelve men is a major health burden worldwide and in our population as well. A total of 180 patients including 30 in control group, 126 osteoporotics and 54 osteopenics, were diagnosed and analyzed with the help of bone mineral density (BMD) by dual energy x-ray absorptiometry (DEXA) and treated in different groups with...
May 2013
Synthesis of three formamidine disulphide derivatives as potential integrase inhibitors of human immunodeficiency virus (HIV)
Three analogues of formamidine disulphide (FMD) were synthesized as potential integrase inhibitor of human immunodeficiency virus (HIV). Piperonal, 3-Nitrobenz-aldehdye and 3,4,5-trimethoxybenzaldehyde, were respectively coupled with formamidine disulphide to prepare piperoformamidine disulphide (P-FMD), 3-Nitro-formamidine disulphide (N-FMD) and 3,4,5-trimethoxyformamidine disulphide (T-FMD). The structures of the...
May 2013
Metabolic changes of glutathione in human T and B lymphocytes induced by organo-aluminum complex
Even though aluminium is not considered to be a heavy metal like lead, silver, arsenic and cadmium, it can be toxic when taken in excessive amounts and even in small amounts if deposited in the brain. Glutathione, a major antioxidant in the cells, so its depletion weakens the tissue resistance to oxidant. Glutathione is the sulfhydryl (-SH) antioxidant, antitoxin and enzyme cofactor which plays an important role in...
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