African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 29 April, 2012; 6(16)

April 2012

Down-regulation of ghrelin receptors in the stomach delays gastric emptying in vagotomized rats

Ghrelin promotes gastric emptying and small intestinal transit when injected through central or peripheral channels in experimental animals. When the vagal nerve is cut off, the central effect of ghrelin is abolished, the peripheral effect is still observed. Furthermore, the function of ghrelin receptor expressing nerve cells in gastric muscle layers is affected. Expressional changes in ghrelin receptors may affect the...

Author(s): Wen-Cai Qiu, Cheng-Guang Yang, Jun Yan, Zhi-Gang Wang and Qi Zheng

April 2012

Characterization and antioxidant activity of the complex of sesamol and hydroxypropyl-β-cyclodextrin

Sesamol is a natural antioxidant with good prospect in food and medicine industry. But its poor water solubility limits its application. In this study, the complex of sesamol and HP-β-CD was prepared to improve the water solubility of sesamol. The physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), differential scanning calorimetry (DSC)...

Author(s): Yuxiang Ma, Li Yang, Chungang Chen, Yang Liu and Xuede Wang

April 2012

Association of vitamin D receptor gene polymorphism in Han people with lumbar degenerative disc disease

Vitamin D receptor (VDR) gene polymorphism has a certain relationship in Han people with lumbar degenerative disc disease (LDDD), however, this relationship has not been definitely analyzed so far, thus, the purpose of this study is to analyze the polymorphism of three VDR gene loci and reflect the correlation between VDR gene polymorphism and lumbar degenerative disc disease in Han people. In this study, we collected...

Author(s): Weijian Chen, Guitao Li, Hongtao Sun, Wei Ye, Dongsheng Huang , Peiqiang Suand Zhaotian Zhang

April 2012

Comparison of antimicrobial effect of sodium hypochlorite (5.25%) and Iranian propolis on bacteria isolated from necrotizing single canal tooth with chronic apical periodontitis

The main goal of endodontic therapy is to reverse the process of periapical periodontics by removing such microorganisms from the root canal. Sodium hypochlorite (NaOCl) as common endodontic irrigant, possess problems of toxicity, odor and discoloration of operatory items. An equally effective, but safe irrigant is desirable. The purpose of this study was to compare the anti-microbial activity of propolis with that...

Author(s): Maryam Zare Jahromi, Arezoo Tahmourespour and Roya Foroughi 

April 2012

No association of rs2501431 polymorphism of cannabinoid receptor 2 gene with bone mineral density in Chinese postmenopausal women

The aim of the study is to investigate the association of polymorphism of cannabinoid receptor 2 (CNR2) gene at site rs2501431 with bone mineral density (BMD) in Chinese postmenopausal women. 490 Chinese Han postmenopausal women were randomly enrolled and their BMD were measured by dual-energy X-ray absorptiometry (DEXA) at total body, lumbar spine (L2-L4), femoral neck and trochanter. Genotypes for the CNR2 rs2501431...

Author(s): Xilian Hu, Lingdi Zheng, Quanshen Yang, Haibao Xie, Yazhen Wang, Weihong Xu, Yuandong Lv, Fuzhen Li, Pinghua Tao, Xiaolin Wen, Gengxiang Mao, Bing Lin, Guofu Wang and Jing Yan

April 2012

Proteomic analysis of fluconazole resistance in Candida albicans

The pattern of azoles resistance-related proteins expression in Candida albicans may clarify the mechanism of drug resistance and identify new targets for treatment of Candida infection. We identified proteins differentially expressed in strains between fluconazole-sensitive (CA-3) and resistant (CA-16) C. albicans. Both strains were from the same parent. Proteins were analyzed using...

Author(s): Zhiyuan Wang, Gehua Zhang , Xiaoli Zhang, Si Wu, Xingfeng Yin and Hong Zhang,

April 2012

The effects of tongdujianbu particle treatment on matrix metallopeptidase 9 (MMP-9), tissue inhibitor of metalloproteinase (TIMP)-1, and transformation growth factor (TGF)-β1 expression in a rat model of spinal core injury

This work investigated the effect of tongdujianbu particle (TP) on the expression patterns ofmatrix metallopeptidase 9 (MMP-9), tissue inhibitor of metalloproteinase (TIMP)-1 and transformation growth factor (TGF)-β1 and the behavioural changes in a rat model of spinal cord injured (SCI). A total of 105 adult Sprague-Dawley rats were used for the spinal cord injury as well as different groups of TP treatments. The...

Author(s): Yi Luo, Zhansheng Deng, Shu Huang and Mei Wei

April 2012

A calpain inhibitor elevated expressions of NF-κB in atrial fibrillation canine atria

This aim of this study is to observe the alterations of calpain proteolytic system and effect of a calpain I inhibitor on NF-κB expressions in rapid pacing canine atrial fibrillation (AF) models. Twenty-one dogs were divided equally into three groups: a sham operation group, a control AF group and a calpain inhibitor group. Rapid right atrium pacing at 600 beats per min was applied in the control AF group and the...

Author(s): Hong-Jie Xue, Zhi-Hua Gong, Yue Li, Yong-Tai Gong, Li Sheng, Guang-Zhong Liu, Wei-Min Li and Song-Bin Fu

April 2012

Dual immuno-regulatory effects of Y-40138 in animal models of sepsis and aspiration pneumonitis

We evaluated the dual immuno-regulatory effects of Y-40138, inhibiting tumor necrosis factor (TNF)-α production and augmenting interleukin (IL)-10 productions, in animal models of organ dysfunction related to systemic inflammatory response syndrome. Male Sprague-Dawley rats received Y-40138 (1, 10 and 30 mg/kg) or saline subcutaneously, and were subjected to cecal ligation and puncture (CLP) surgery 15 min later....

Author(s): Hiroyuki Seki, Koichi Suda, Kiyoshi Moriyama, Yoshiki Shiraishi, Koichi Fukunaga, Sadatomo Tasaka, Yuko Kitagawa, Akitoshi Ishizaka and Junzo Takeda

April 2012

Study on the ethnopharmaceutical values and traditional uses of Capparis spinosa L.

This paper highlights the ethno-pharmaceutical importance of Capparis spinosa L. (Capparidaceae) used by many local people of district Chitral since century under the traditional system of medicine. In this context, a survey was conducted during summer 2010 in different ecologically and economically important sites of the study area. The aims, the current endeavour was to prepare an ethno-pharmaceutical...

Author(s): Hassan Sher, Khalid ALMutairi, and Mashhor Mansoor

April 2012

Constituents of the Essential Oil from Leaves and Buds of clove (Syzigium caryophyllatum (L.) Alston)

Essential oil obtained by hydrodistillation from fresh leaves and dry buds of Syzigium caryophyllatum were analyzed by gas chromatography mass spectrometer (GC-MS). Thirty eight components were identified in the leaf oil. The main components were eugenol (74.3%), eucalyptol (5.8%), caryophyllene (3.85%) and a-cadinol (2.43%). Thirty one components were identified in bud oil with the main components being...

Author(s): Mohammad Nazrul Islam Bhuiyan,

April 2012

Effect of oxidative and temperature stress on viability and toxin production of environmental isolates of Escherichia coli

The effect of oxidative stress on expression of virulence factors and the effect of low temperature stress on toxin production among Escherichia coli serotypes isolated from wastewater and river water samples were determined. Oxidative stress due to chemicals, salts, alcohol or low temperature stress exerted various degrees of lethality to the bacterial cells with bacterial strains losing their potential to...

Author(s): James Hamuel Doughari, Patrick Alois Ndakidemi, Izanne Susan Human and Spinney Benade

April 2012

Repair of bone defect using bioglass-chitosan as a pharmaceutical drug: An experimental study in an ovariectomised rat model

Bone loss associated with skeletal trauma or metabolic diseases often require bone grafting. The present study aimed to evaluate the performance of bioactive glass-chitosan composite (BG-CH) produced by a freeze-drying process. BG containing 17% wt% CH was implanted in the femoral condyl of an ovariectomised rat. The resected bone was prepared for analysis using several physico-chemical techniques such as fourier...

Author(s): Samira Jebahi, Hassane Oudadesse, Bui XV, Hassib Keskes, Tarek Rebai, Abdelfattah el Feki and Hafed el Feki

April 2012

Effect induced by Tabebuia rosea on glucose concentration in a rat diabetic model

Diabetes is an important human ailment afflicting many from various walks of life in different countries. Since several years ago, medicinal plants are being looked up once again for the treatment of diabetes. In this sense, the objective of this study was to evaluate the hypoglycemic activity of Tabebuia rosea in a diabetic rat model. The ethanolic and chloroformic extracts of T. rosea crust were...

Author(s): María López-Ramos, Lauro Figueroa-Valverde, Francisco Díaz-Cedillo, Elodia García-Cervera and Eduardo Pool-Gómez