African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 29 August, 2012; 6(32)

August 2012

The preliminary study of the mechanism and efficacy of non-steroidal anti-inflammatory drug treatment on nerve root type cervical spondylosis

This study aims to evaluate the cyclooxygenase-2 (COX-2) protein expression in spinal cord dorsal horn of rats with nerve root type cervical spondylosis (NRCS) and the clinical efficacy of different non-steroidal anti-inflammatory drugs (NSAIDs) treatment on Chinese patients with NRCS. 24 Sprague-Dawley (SD) rats were randomly divided into normal health group and NRCS model group, The COX-2 protein expression in spinal...

Author(s): Haibin Lin, Xuanhuang Chen, Guodong Zhang and Xianwei Wu

August 2012

A meta-analysis of the efficacy and safety of cilnidipine in Chinese patients with mild to moderate essential hypertension

The purpose of this study was to evaluate the efficacy and safety of cilnidipine tablets to treat Chinese patients with mild to moderate essential hypertension, and to examine the ability of cilnidipine to lower blood pressure without eliciting unfavorable side effects. Medical databases and review articles were screened for randomized controlled trials (RCTs) that reported the effects of adverse reactions to...

Author(s): Xu Guo-liang, Xu Hui, Wu Hai-di and Qin Ling

August 2012

Comparative effects of propolis of honey bee on pathogenic bacteria

Propolis is one of the useful products in the hive. This substance is a natural product derived from plant resins gathered by honey bees. Its protective properties are because of the components that contribute in propolis production. So far, more than 300 different combinations, such as polyphenols, aldehydes, phenolic, monoterpene, amino acids, steroids and other inorganic compounds are found in the structure of...

Author(s): Shahin Gavanji, Behrouz Larki, Alireza jalali Zand, Elmira Mohammadi, Mohammad Mehrasa and Amir Hosein Taraghian

August 2012

Investigation of temperature-induced physical instability of preserved coenzyme Q10-loaded (NLC): A comparative study at different temperatures

In this work, physical stability of coenzyme Q10 nanostructured lipid carriers (NLC) with and without selected preservatives was investigated at 4 and 40°C and compared to those obtained at 25°C. The NLC dispersions were produced using the hot high pressure homogenization, and physical stability was evaluated in terms of particle size and zeta potential analysis. At 40°C, six preserved coenzyme Q10 NLC were...


August 2012

Development and validation of high-performance liquid chromatographic-ultraviolet (HPLC-UV) method for the bioequivalence study of atorvastatin

A sensitive and rapid high-performance liquid chromatographic method with ultraviolet detection was developed and validated for the determination of atorvastatin in human plasma. After separation of drug from plasma samples and following protein precipitation, the chromatographic separation was accomplished using C18 analytical column. The mobile phase consisted of methanol, acetonitrile, and sodium phosphate...

Author(s): Muhammad Sher, Ghulam Hussain, Muhammad A. Hussain, Taslim Akhtar, Muhammad R. Akram, Rizwan N. Paracha and Ghulam Murtaza

August 2012

ERCC1 and ERCC2 polymorphisms predict the clinical outcomes of oxaliplatin-based adjuvant chemotherapy in colorectal cancer

Platinum agents have shown to be effective in the treatment of colorectal cancer. We conducted a prospective study to investigate the effect of excision repair cross-complementation group 1 (ERCC1 rs11615C>T) and Excision repair cross-complementation group 2 (ERCC2 rs13181T>G) on the efficacy of oxaliplatin-based adjuvant chemotherapy in colorectal cancer patients. A total of 335 cases newly diagnosed by...

Author(s): Lei Shi, Ran Wang, Wen-ming Wu and Yi-fei Huang

August 2012

Dihydroartemisinin suppresses cell proliferation, invasion, and angiogenesis in human glioma U87 cells

Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, which is a well tolerated and effective drug for malaria treatment, has shown potent antitumor ability. This study is explored to evaluate whether DHA can inhibit glioma cell proliferation, invasion, and glioma cell mediated angiogenesis. We determined the glioma U87 cell proliferation by Cell Counting Kit-8 (CCK-8) assay, fluorescence, and flow...

Author(s): Xiangrong Chen, Hong Lin, Jun Wen, Qingshan Rong, Weiwei Xu, Xiangyu Wang