African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 29 February, 2012; 6(8)

February 2012

Rapid improvement in medically ill elderly patients treated with methylphenidate for apathy

Apathy is commonly seen in elderly patients with co-morbid medical conditions. It adversely affects the motivation and recovery of the patients. There is no standard treatment for apathy but antidepressant with slow onset is often the drug of choice. Methylphenidate, a psychostimulant with rapid onset, offers an alternative therapeutic option. We reported two cases of elderly patients who presented with withdrawn and...

Author(s): Lee H. M., Gill J. S., Pillai S. K. and Ng C. G.

February 2012

Chamomile: An ancient pain remedy and a modern gout relief - A hypothesis

Matricaria chamomilla (MC) is a well-known medicinal plant. In the present paper, the researchers intended to focus on the possible anti-inflammatory pharmacological mechanisms of MC preparations in the treatment of gouty arthritis and the constituents of MC responsible for its effects. The medicinal preparations of MC are composed of several classes of biologically active compounds...

Author(s): Hamed Ghavimi, Ali Shayanfar, Sanaz Hamedeyazdan, Afshin Shiva, Afagh Garjani

February 2012

Effect of various fractions of Launaea procumbens on antioxidant enzymes in rats liver: Oxidative stress induced by potassium bromate (KBrO3)

Launaea procumbens is traditionally used in the treatment of liver dysfunction and hepatitis. In the present study, protective effects of L. procumbens against potassium bromate (KBrO3)-induced hepatotoxicity of rat were determined. However, 36 male albino rats (180 to 200 g) were equally divided into 6 groups. Group I was given saline (1 ml/kg b.w., 0.85% NaCl) and dimethyl sulfoxide (DMSO) (1 ml/kg...

Author(s): Rahmat Ali Khan, Muhammad Rashid Khan, ,Sumaira Sahreen, Naseer Ali Shah, Amir Muhammad Khan, Yar Muhammad Khan, Jasia Bokhari, Umbreen Rashid, Bushra Ahmad, Maria Shabbir, Naima Saeed, Shumaila Jan and Tayyaba Afsar

February 2012

Antiplasmodial activity of quinine-zinc complex and chloroquine: A comparative in vitro assessment

The evolving and complicating drug resistance exhibited by strains of Plasmodium falciparum to existing antimalarials like chloroquine and quinine (which are relatively more affordable than recent drugs) and advances in metal-drug complex research instigated this work. The antiplasmodial activity of the Quinine-Zinc complex (QZ) synthesized by a modification of the method of Singla and Wadhwa was assessed...

Author(s): O. O. Ogunlana, O. E. Ogunlana and O. G. Ademowo

February 2012

Treatment of cesarean scar pregnancy complicated with massive hemorrhage

The present study investigated suitable measures for treating cesarean scar pregnancy (CSP) complicated with massive hemorrhage. A total of 14 cases were diagnosed as CSP complicated with massive hemorrhage, and were treated from May 2003 to August 2009. Analyses of various factors related to hemorrhaging were carried out. According to the blood β-human chorionic gonadotropin (HCG) level, hemorrhaging onset...

Author(s): Huajiang Shao, Jianting Ma, Liping Xu, Xiuer Yang and Xuefeng Su

February 2012

Safety aspects of chronic myeloid leukemia pharmacotherapy

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder of pluripotent stem cells, first described by John Hughes Bennett in 1845. Previously, the treatment options, such as hydroxicarbamide, interferon, busulfan and radiotherapy, only controlled the disease while the novel therapeutic options increased significantly the rate of remissions. Untreated patients in chronic phase (CML-CP) inevitably...

Author(s): Alexandra Savova, Assena Stoimenova, Manoela Manova and Guenka Petrova

February 2012

Poly (amido amine) dendrimer silences the expression of epidermal growth factor receptor and p53 gene in vitro

To understand more about the lower generations of poly(amido amine) dendrimer (PAMAM) as a non-viral vector for antisense (ANS) therapy, a 21-mer epidermal growth factor receptor (EGFR) ANS was delivered by generation five of PAMAM in T47D breast carcinoma cells in culture. The semi-quantitative polymerase chain reaction (PCR) and western blot analysis were used to quantify the expression of EGFR mRNA and protein,...

Author(s): Alireza Nomani, Shamileh Fouladdel, Ismaeil Haririan, Ramin Rahimnia, Marika Ruponen, Tarane Gazori, Ebrahim Azizi,

February 2012

Immobilization stress-induced oxidative damage and its amelioration with green and black teas

Stress is a state of vulnerable cellular homeostasis, which results in free radical generations and subsequent oxidative damage. The aim of this study is to evaluate the effect of green and black teas on immobilization stress-induced oxidative damage in male Wistar albino rats. Six weeks of repeated immobilization for 4 h daily for five consecutive working days per week was applied. Green or black teas were...

Author(s): Salim S. Al-Rejaie, Hatem M. Abuohashish, Mohammed M. Ahmed, Abdulaziz M. Aleisa, Abdulaziz S. Alroujayee and Osama A. Alkhamees

February 2012

Protective effect of erythropoietin on spinal ischemia-reperfusion injury

Our study aimed at investigating the protective effect of erythropoietin (EPO) on the spinal ischemia/reperfusion (I/R) injury in a murine model and exploring the potential mechanism. Adult male mice were subjected to spinal IR injury. The aortic arch and proximal left sub-clavianarteries were obstructed by clamping for 5 min and the animals were monitored for 48 h. The neurological function of hind limb was...

Author(s): Zhaowei Teng, Jinghua Lu, Guojun Wei, Yugang Liu and Xiguang Zhang

February 2012

Hepatoprotective effects of antioxidants against non-target toxicity of the bio-insecticide spinosad in rats

The bio-insecticide spinosad (SPD) is increasingly being used in pest management programmes. In order to further assess its toxic effects to non-target species, male rats were exposed sub-chronically to SPD at a dose equivalent to 1/20 LD50 for four weeks. In order to assess the toxicity of SPD, parameters such as the activities of enzymes and concentrations of non-enzymatic antioxidant components,...

Author(s): Ahmed M. Aboul-Enein, Mourad A. M. Aboul-Soud, Hamed K. Said, Hanaa F. M. Ali, Zeinab Y. Ali, Amany M. Mahdi and John P. Giesy,,,

February 2012

In vitro toxicity screening of polyphyto combination using Caco-2-cell line

The aim of the research work is polyphyto combination compression of different antilithiogenic agent and to screen its toxicity by Caco-2-cell line. Polyphyto combination was prepared by geometrical dilution method; it was subjected for aqueous and alcoholic extract. The formulation and extract were screened for its initial in vitro toxicity study using Caco-2-cell line by 3-(4, 5 dimethyl thiazole-2-yl)-2,...

Author(s): K. Upadhayaya, N. V. Stheesh Madhav and B. Abhishek