July 2015

Pharmacokinetics of isoniazid in 30 tuberculosis patients in Abidjan, Côte d'Ivoire

Isoniazid is a major component in tuberculosis (TB) treatment, which is often used in combination or alone as prophylaxis for its high efficiency on bacilli of Mycobacterium tuberculosis. It is responsible for an increased risk of developing serious liver side effects involving the prognosis of the patient. Its coinfection with HIV is currently a real public health problem. The purpose of this study was to establish the...

Author(s): Djadji A. T. L. , Kouakou A. F. , Kamagaté M. , Siransy-Kouakou G. Bekegnran C. , Abrogoua D. P. , Kablan B. J. , Dié-Kacou H. , Eholie S. P.  and  Garraffo R.

July 2015

Ameliorating effect of combination of simvastatin and residronate on glucocorticoid induced osteoporosis model in rats

Osteoporosis is one of the major problems facing older people of both sexes. This study was undertaken to investigate the synergistic effects of combination of statins and bisphosphonates in a glucocorticoid-induced osteoporosis (GIO) model. Thirty rats were divided into five groups; control group (I), GIO group (II) (given oral prednisolone, pred 30 mg/kg, per 2 days for 6 weeks), group III (treated by pred +...

Author(s): Ahmed Shata, Alaa El-Din L. Firgany and Ahmed A.M. Abdel-Hamid