African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 29 November, 2012; 6(44)

November 2012

A review of medicinal plant species with elemene in China

Some researchers suggest that many plant species or extracts have medicinal value; in particular, some have great antitumor potential. Rhizoma curcuma is the dried roots ofCurcuma phaeocaulis, C. kwangsinensis and C. wenyujing in Chinese herbal medicine and the essential oil from it has been shown to inhibit tumor cell growth mainly due to its elemene component. Elemene has marked the...

Author(s): Shuling Wang, Zhenkun Zhao, SUN Yun-ting,Zhaowu Zeng,Xiaori Zhan,Chenglu Li and Tian Xie

November 2012

Morphine use in elderly patients with acute heart failure

Morphine has been considered as an important medicine to treat acute heart failure (AHF) for a long time. This study was designed to explore the usage rate of morphine in emergency department and its influence on the prognosis of the elderly patients with AHF in china. A prospective investigation of elderly patients with AHF, who were treated and admitted from emergency room of the General Hospital of the People's...

Author(s): Yanhua Li#, Qiang Xu#, Lili Liu, Haiyan Zhu and Xiaoyong Sai

November 2012

Biotransformation of 3,4-cyclocondensed coumarins by transgenic hairy roots of Polygonum multiflorum

Two new coumarin glycosides (5 and 6), together with one known compound (4), were biosynthesized by transgenic hairy roots of Polygonum multiflorum with three 3,4-cyclocondensed coumarins as substrates (1 to 3). Their structures were elucidated by physicochemical and extensive spectroscopic analyses. The results of this study demonstrated that the hairy roots of P. multiflorum have the...

Author(s): Ling Liu#, Minghua Zhang#, Liangbin Zhou, Jianhua Zhu, Shixia Guan and Rongmin Yu

November 2012

Changes in detrusor excitability and C-kit, connnexin-43 expression in rats after spinal cord injuries

The current study aims to explore the possible correlations between detrusor excitability and the expression of C-kit and connexin-43 (Cx43). Fifty-two adult female Sprague Dawley (SD) rats were randomly divided into the normal control (NC), supra-sacral cord injury (SSCI) and sacral cord injury (SCI) groups. Neurogenic bladder models were established. Urodynamic examination, bladder pathological observation and...

Author(s): Hua-mao Jiang, Shu-bin Si, Shuqi Du, Zhenhua Li, De-wang Fu, Xiao-peng Wang and Bin Song

November 2012

Complexation of BaCl2 with glutathione (GSH) in blood components

Barium is a divalent alkaline earth metal and can exist only in combination forms. Studies have proved that barium can cause different toxic effects. The human body can be exposed to barium in drinking water, food and air. In medical field, barium is used in diagnostic procedure. Among its various combinations, barium chloride is considered most important in its related toxicities, because of its water solubility. In...

Author(s): Javed Khan, Muhammad Farid Khan, Haroon Khan, Barkat Ali Khan, Naseem Ullah, Naheed Haque, Muhammad Mukhtiar and Arshad Farid

November 2012

2,3,4’,5-Tetrahydroxystilbene 2-O-β-D-glucoside prevents vascular endothelial dysfunction in a type 2 diabetic rat model

The aim of this study was to investigate the effect of 2,3,4’,5-tetrahydroxystilbene 2-O-β-D-glucoside (TSG) on vascular endothelial dysfunction in the type 2 diabetes rats, and the possible mechanisms. Sprague-Dawley rats were treated by high-fat diet and intraperitoneal injection of streptozotocin (40 mg/kg) to induce type 2 diabetes. TSG (60 or 120 mg/kg per day) was administered by oral gavage for 6...

Author(s): Yuan Zhang, Lin Dong, Xiao-le XU, Yan-juan Huang, Xiang-fan Chen, Yu-qin Wang and Wei Zhang

November 2012

Expression and clinical significance of matrix metalloproteinase 9 (MMP9) papillary thyroid carcinomas

Matrix metalloproteinases (MMPs) play a crucial role in tumor invasion and metastasis. There have been only a few studies on the MMP expression in thyroid carcinomas. Therefore, we investigated the MMP9 expression in 66 papillary thyroid carcinomas (PTC) using immunohistochemistry and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) on protein level and mRNA level, respectively. We also examined...

Author(s): Xianying Meng, Tebo Hua, Qiang Zhang, Renzhu Pang, Guibin Zheng and Dong Song

November 2012

The effects of Ginkgo biloba L. and Camellia sinensis L. extracts on oxidative stress in patients with type 2 diabetes

n the case of diabetes, hyperglycemia appears to be a significant contributor to oxidative stress which is also linked to diabetes related complications. In this study, we evaluated the effects of Ginkgo biloba L. and Camellia sinensis L. leaves extracts on oxidative damage in type 2 diabetic patients with surrounding diabetic complications. We found no significant effects of Green tea...

Author(s): Asta Spadiene, Nijole Savickiene, Andrejs Skesters, Alise Silova and Hiliaras Rodovicius

November 2012

Antimicrobial activities and time kill profiles of five essential oils from Southern Africa against selected bacterial and fungal organisms

Essential oils are complex mixtures of volatile secondary metabolites from plants. In this study, essential oils from five plants traditionally used to treat infectious diseases were tested for antimicrobial activity against seven Gram-positive bacteria, eight Gram-negative bacteria and six yeast species (Candida species and Cryptococcus neoformans) using the agar diffusion method. The minimum inhibitory...

Author(s): A. Samie, T. Nefefe, M. Gundidza, V. Mmbengwa, M. Magwa and M. S. Mtshali

November 2012

Dermatological potential of crude extracts and different fractions of Achyranthes aspera Linn.

Achyranthes aspera (Prickly chaff) seeds contain spines which often cause irritation on the hands of those who collect them. The main objective of this investigation was to evaluate its irritant potential on animal's skin. Skins irritating chemical constituents were separated in the form of various fractions. For this purpose, solvents of different polarities were successively used to extract least-polar...

Author(s): Saeed ul Hassan, Shahid Rasool, Uzma Niaz, Muhammad Khalil Rehman, Muhammad Yasir Ali, Ghulam Abbas, Nasir Rasool, Muhammad Riaz and Khizar Abbas