April 2012
Pharmacological effects of two polar fractions from Annona coriacea Mart in animal models
In the current investigation, the antinociceptive and anti-inflammatory effects of the ethyl acetate and butanol fractions from Annona coriacea leaves were evaluated using standard experimental test models. The antinociceptive activity of A. coriacea was studied by acetic acid-induced writhing, formalin and hot-plate tests, and the anti-inflammatory activity was determined by carrageenan-induced...
April 2012
Hepatoprotective effect of Lysimachia paridiformis Franch. var. stenophylla Franch. on CCl4-induced acute liver injury in mice
As Chinese folklore medicine, Lysimachia paridiformis Franch. var. stenophylla Franch. (LPF) has been used for treatment of various diseases such as rheumatism and hemiplegia. Our previous studies have shown that LPF have strong antioxidant activity in vitro. Nevertheless, there have been no reports on the hepatoprotective effect of the extracts of LPF in animals. The aim of this study...
April 2012
Apoptotic effects of dehydroepiandrosterone sulphate (DHEAS) of the human promyelocytic leukemia cell (HL-60)
Dehydroepiandrosterone sulphate (DHEAS) has a protective role against cancer; however, the mechanism by which DHEAS has this effect remains poorly understood. The purpose of this study was to investigate the potential effects of DHEAS on HL-60 (human promyelocytic leukemia cell). The percentage of cells undergoing apoptosis was analyzed by flow cytometry using Annexin V-fluorescein isothiocyanate staining. DHEAS...
April 2012
Proximate composition, antimicrobial and antioxidant activities of six wild edible celeries (Smyrnium L.)
In this study, proximate composition, antimicrobial and antioxidant activities of six Smyrniumtaxa, including, Smyrnium olusatrum, Smyrnium perfoliatum, Smyrnium rotundifolium,Smyrnium cordifolium, Smyrnium connatum and Smyrnium creticum (Umbelliferae) were determined. Antioxidant properties of methanol extracts were studied by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free...
April 2012
Study on the medicinal plant Calandula officinalis
The antibacterial and anti-fungal activities of the methanol and its sub fractions of chloroform, ethyl acetate, and water extracts of the roots, stem and leaves of Calendula officinalis were carried out against bacterial strains, Staphylococus aureus, Klebsiella pneumoniae, Salmonella typhymurium and Escherichia coli, and fungal species including Aspergilla fumigates, Fusarium...
April 2012
Anti-Malassezia furfur activity of essential oils against causal agent of Pityriasis versicolor disease
Potential inhibitory effect of Citrus lemon (lemon) and Citrus sinensis (orange) on lipophilic, yeast like fungus Malassezia furfur which causes Pityriasis versicolor, chronic superficial fungal disease of the skin have been studied using two different methods: Disc diffusion and microdilution methods. In screening of lemon and orange oil by disc diffusion method, the diameter of...
April 2012
High mobility group in A1a (HMGA1a) small interfering RNA (siRNA) blockage decreases metastatic potential in cultured osteosarcoma cell lines
High mobility group A1 (HMGA1) is a non-histone chromosomal nuclear protein that plays important roles on gene transcription, recombination, and chromatin structure stabilization. The aim of this study was to investigate the effect of small interfering RNA (siRNA) on HMGA1 expression and metastatic potential in osteosarcoma cell in vivo. We obtained osteosarcoma cell sublines after single cell cloning technique...
April 2012
Antinociceptive, antiinflammatory and antioxidant activities of ethanolic extract of Cancrinia discoidea (Ledeb.) Poljak
Antinociceptive, anti-inflammatory, and antioxidant activities of ethanolic extract of Cancrinia discoidea (Ledeb.) Poljak. (EEC) was evaluated. Intraperitoneal (IP) administration of EEC, in all the tested dose levels (100 to 300 mg/kg), exhibited significant dose-related inhibition of acetic acid-induced writhing and formalin induced nociception, exhibited significant dose-related inhibition of carrageenin...
April 2012
Preparation of triptolide ethosomes
Filming-rehydration and ultrasonic method were combined to prepare ethosomes as a carrier of triptolide. A laser dynamic scattering instrument was used to determine the particle size of ethosomes. The average particle size was calculated based on the measurements of five different batches of ethosomes. To determine the entrapment efficiency, free triptolide was isolated by ultracentrifugation. The concentration of...
April 2012
Testing willingness to pay for blood pressure measurement in community pharmacy
The Bulgarian primary healthcare system was faced by a number of challenges: The demands of an aging population, the growing strain on the primary healthcare services and a change in the daily activities of pharmacy and other primary healthcare professionals. These changes for community pharmacist are reflected more generally in contributing to accessible and efficient primary healthcare services, known as value-added...
April 2012
Study on the anti-dementia and neural protection effects of ethamol soluble extract of Polygalae Radix
Polygalae radix, the root of Polygala tenuifolia Willd, has been widely used as a drug for the treatment of amnesia, calm, convulsions, aging, physical weakness, abnormal intelligence, etc, in traditional Chinese medicine. Recent research indicated that Polygalae radix has the function of neural protection. Extractions and fractionation of Polygalae radix were used as effective compounds in this research,...
April 2012
Time dependent response in ghrelin levels in mesenteric ischemia in rat
The objective of this study was to determine the value of time-dependent ischemia-modified ghrelin in mesenteric ischemia. The authors investigated whether or not there is changes in plasma ghrelin levels in the acute period in a rat model of mesenteric ischemia were time-related. 42 mature male rats were divided into seven groups: one control and six ischemia groups. In the ischemia groups, following laparotomy the...
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