African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 8 July, 2012; 6(25)

July 2012

Pharmacologic and medicinal properties of Allium hirtifolium Boiss

Allium hirtifolium is known as wild garlic and it grows wild just in Iran. A. hirtifolium extracts are important areas in drug development with numerous pharmacological activities. For a long time, A. hirtifolium has been used in traditional medicine for treatment of hypertension, rheumatoid, inflammation, and also wounds healing. A. hirtifolium has recently been shown to have...

Author(s): Jinous Asgarpanah and Bahareh Ghanizadeh

July 2012

The protective effect of 7-difluoromethylgenistein on oxidative stress injury induced by hydrogen peroxide in PC12 cell line

7-Difluoromethylylgenistein (FMG), prepared by the difluoromethylation and alkylation of genistein, is an active new chemical entity. The protective effect of FMG on PC12 cell injury by oxidative stress was studied, and its molecular mechanism of action was also investigated. This paper demonstrated that pretreatment with FMG could improve cell growth and proliferation in a concentration dependent manner, reduce the...

Author(s): Xing Feng, Mei-Ling Tao, Xiao-Hua Fu, Hong-Lin Xiang and Jian-Guo Cao

July 2012

Investigation of macro and micro-nutrients in selected medicinal plants

Heavy metals contents including Fe, Zn, Ni, Cr, Pb, Cu, Cd and Ag and inorganic constituents like HCO3-, CO3-2, Ca+2, Mg+2, Cl-, Na+, K+, SO4-2, NO3-, Fe+2 and F- are quantitatively determined in Citrolus colocynthis, Opuntia monocantha, Gallium apparine, Foeniculum vulgare, Equisetum arvensis, Hypericum perforatum, Carthamus lanatus and Cichorium intybus collected from Khyber Pakhtunkhwa...

Author(s): Riaz Ullah, , Jameel Ahmed Khader, Iqbal Hussain, Naser Mohamed AbdElsalamMuhammad Talha and Naeem Khan

July 2012

The use of dexmedetomidine in aged patients with total hip replacement surgery under general anesthesia: Changes in hemodynamics, cerebral state index and wakening quality

This research work was carried out to understand how dexmedetomidine (Dex) administration caused changes in hemodynamics [systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR)] and cerebral state index (CSI) in aged patients undergoing total hip replacement (THR) surgery and general anesthesia. Sixty (60) years aged patients undergoing total hip replacement THR surgery and general anesthesia...

Author(s): Jun Zhou, Jie Wang and Fanmin Meng

July 2012

Enalaprilat-induced cardiac fibroblast proliferation via regulation of transforming growth factor beta 1 (TGF-β1)-expressing anti-angiotensin II (Ang II)

The objectives of this study were to investigate the effects of the angiotensin I-converting enzyme inhibitor enalaprilat (Ena) on the proliferation, hydroxyproline content, and transforming growth factor β1 (TGF-β1) protein expression of neonatal cardiac fibroblasts and to probe its anti-cardiac fibrosis mechanism. Cardiac fibroblast (CFb) was isolated using the trypsin digestion method. Methyl thiazolyl...

Author(s): Du-Juan Yu, Li-Jun Xu, Min Yu, and Hong-Xia Sun

July 2012

Modulation of renal redox status by garlic based on route of administration in rat

Several controversies persist about the beneficial or toxic effects of garlic. The present study was undertaken to determine the effects of high dosage garlic according to its mode of administration in rat. We studied the ability of high dosage garlic to modulate kidney antioxidant status when administered either orally (PO) or by intraperitoneal (IP) route. In renal tissue homogenate, PO garlic was antioxidant as it...

Author(s): Sonia Hamlaoui, #, Oumayma Samti#, Meherzia Mokni, , Nadia Limam, Ferid Limam, Ezzedine Aouani, Mohamed Amri and Lamjed Marzouki,

July 2012

Study on correlation between expression of Kiss-1 and matrix metalloproteinase-9 (MMP-9) proteins, metastasis and prognosis in colorectal carcinoma

The expression of Kiss-1 and matrix metalloproteinase-9 (MMP-9) proteins and their effect on pathogenesis, development and metastasis in colorectal carcinoma were investigated. To clarify the correlation between the expression of Kiss-1 and MMP-9 with different indexes and clinicopathologic characteristics by immunohistochemistry (IHC), 67 cases of colorectal carcinoma tissue were collected as experimental group as well...

Author(s): Haiqin Wang, Guoshun Shu and Jirong Huo

July 2012

Bioactivity potential of extracts from ascidian Lissoclinum fragile

Ascidians are marine biofouling animals with a proven ability to synthesis bioactive substances. This study investigated the bioactive potential of ascidian Lissoclinum fragile,found in the coastal waters of Tuticorin Southeast coast of India. Freshly collected ascidian soaked in methanol for five days and filtered through filter paper. The solvent was concentrated by rotary evaporator which reduced...

Author(s): N. Sri Kumaran, S. Bragadeeswaran, T. Balasubramanian and V.K Meenakshi

July 2012

Effects of levamisole on the immune response of broilers against Newcastle disease vaccines

The efficacy of levamisole (LMS) hydrochloride, a standard immune modulator, was conducted on 240 broilers using different commercial Newcastle disease (ND) vaccines. La sota, Clon 30 and Avinew vaccines were used in this study. Treated groups received 30 mg/kg of LMS in drinking water for 2 days before and 2 days after each vaccination. Vaccination program were based on routine vaccination in Urmia area. Blood samples...

Author(s): Mostafa Habibi, Mohammad Amin Zandieh, Hasan Ghahri, Reza Salman Zadeh and Farid Yeganeh

July 2012

Risk factors analysis of severe acute pancreatitis complicated with acute cholecystitis in later stage

To explore the risk factors and clinical significance of severe acute pancreatitis (SAP) complicated with acute cholecystitis (AC) in later stage. With case-control study method, collected clinical data of 42 cases of SAP complicated with AC patients (the experimental group) and 210 cases of SAP patients (the control group) from March, 2002 to March, 2011. Then used single factor non-conditional logistic...

Author(s): Lin Ouyang, Can Hou, Zhihui He, Guobao Wu and Youdi Lv

July 2012

Transurethral photoselective vaporization: A safe and effective treatment for glandular cystitis

To evaluate the clinical efficacy and safety of transurethral photoselective vaporization in the treatment of glandular cystitis, 125 cases with glandular cystitis were treated with transurethral photoselective vaporization from 2004 to 2010. The patients’ hospital records were reviewed to obtain pre-operative, intra-operative and post-operative data. All the patients were diagnosed with glandular cystitis through...

Author(s): Wei Tao, Yuxi Shan, Dongrong Yang and Wei Qian

July 2012

Vitexicarpin induces apoptosis-independent mitotic arrest in U87 glioblastoma cells

Glioblastoma multiforme is the most common and lethal primary brain tumor that responds poorly to currently available chemotherapy. Vitexicarpin, a flavonoid compound has been reported to exhibit anti-proliferative activities against various cancer cell lines. However, the anticancer effect of vitexicarpin on glioblastoma remains unexplored. In the present study, we found that vitexicarpin inhibited the growth of U87...

Author(s): Chonghao Wang, Jianguo Zhang, Zhongcheng Wang, Muhammad Razzaq and Muhammad Khan

July 2012

Development and evaluation of pectin based colon targeted herbal drug delivery system

The objective of present investigation was to develop rhubarb matrix tablets intended for colon specific delivery system (CoSDS) using two combined approaches of biodegradable microflora-activated system with a pH-sensitive system. Matrix tablets of rhubarb were prepared by wet granulation method using polysaccharide, that is, pectin (10%) alone and in combination with hydrocolloids, that is, hydroxypropyl...

Author(s): Biraju D. Patel, Dhaval V. Patel, Jayant R. Chavda, Mahesh R. Dabhi and Ravi A. Manek