African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 8 June, 2012; 6(21)

June 2012

Oxidation of glutathione (GSH) in blood plasma due to oxidative stressors: A case study of silver

The widespread use of silver went out of fashion with the development of modern antibiotics. However, recently, there has been renewed interest in silver as a broad spectrum antimicrobial. The toxicity of silver to human cells is considerably lower than that of bacteria. Silver itself is nontoxic, but most silver salts are, and some of them are to be carcinogenic and may lead to death. That is why the effect of silver...

Author(s): Haroon Khan, M. Farid Khan, Barkat Ali Khan, Abdul Wahab, Syed Umer Jan, Muhammad Mukhtair, Naseem Ullah, Naheed Haque and Arshad Farid

June 2012

A meta analysis of the efficacy of Saccharomyces boulardii in children with acute diarrhea

This study was performed to evaluate the efficacy of Saccharomyces boulardii in treating children with acute diarrhoea. Medicinal databases and review articles were screened with prespecified criteria for randomized controlled trials that reported the effects of S. boulardiiand other antidiarrhoeal drugs in treating children with acute diarrhoea. The quality of the study was critically evaluated. A total...

Author(s): Jun Pan, Jiang Hu, Xusheng Qi and Ziliang Tu

June 2012

Effects of syringin from Phellodendron chinensis on monosodium urate crystal-induced inflammation and intercellular adhesion molecule-1 (ICAM-1) expression

Syringin is a phenylpropanoid glycoside isolated from the bark of Phellodendron chinensis Schneid. The present work was designed to examine the effects of syringin on the protection and expression levels of adhesion molecules in human umbilical vein endothelial cells (HUVECs) induced by monosodium urate (MSU). Syringin treatment increased the MSU-induced HUVEC viability as assessed by the 3-(4,...

Author(s): Lian Yin, Yan-hua Yang, Ming-yan Wang, Xu Zhang and Jin-ao Duan

June 2012

1Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China. 2Apothecary of Changzhou Seventh People's Hospital of Jiangsu, Changzhou 213011, China. 3Key Laboratory for Modern Research of Traditional Chinese Medical Formula of Jiangsu, Nanjing 210046, China.

This study aims to investigate the effects of clausenamide on streptozotocin (STZ)-induced diabetes in rats. The diabetic rat model was established via an intraperitoneal STZ injection. The rats were randomly divided into five groups, the normal control group, the model group, the insulin treatment group, the high-dose clausenamide treatment group, and the low-dose clausenamide treatment group. Three months after drug...

Author(s): Ruan-Ling Hou, Ling-Yun Bi, Feng Wang, Xiao-Juan Li, Dong-Liang Li and Xian-Hong Dong

June 2012

High-resolution melting sequence matching screening in N-acetyltransferase 2 single nucleotide polymorphism (rs1801280 341T>C)

Genotyping N-acetyltransferase 2 (NAT2) for acetylation status of its enzyme is very important for personalized medicine, especially individualized dosing of anti-tuberculosis drugs and in bladder cancer epidemiology. Human NAT2 gene with at least 359 single nucleotide polymorphism (SNP) accessions is highly polymorphic which makes it difficult to design specific primers for allele specific PCR. Because of this,...

Author(s): Irem Uzonur and Derya Sultan Karabulut

June 2012

Antitumor effect of N-(4-chlorophenyl)-5,6,7-trimethoxyquinazolin-4-amine dihydrochloride on tumor cells in vitro

Previous evidence demonstrated the antitumor ability of quinazolines and its derivatives. In this study, the anticancer activities of N-(4-chlorophenyl)-5,6,7-trimethoxyquinazolin-4-amine dihydrochloride against four kinds of cell lines were evaluated by 3-(4,5-dimeth-ylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The bioassay results indicated that title compound possessed wide spectrum of anticancer...

Author(s): Yinjiu Huang, Lin Su, Hongzhen Wang, Xiaomei Hu, Gaofeng Liu and Baoan Song

June 2012

Suppression of STAT3 phosphorylation enhances the cytotoxicity of cucurbitacin B in B16F10 melanoma cells

Cucurbitacin B (CuB) is a triterpenoid compound extracted from Cucurbitaceae plants, which has been shown to induce the phosphorylation (activation) of signal transducer and activator of transcription 3 (STAT3) in melanoma cells. In this study, we aimed to investigate whether inhibition of STAT3 phosphorylation could influence the cytotoxicity of CuB in melanoma cells. The results showed that pretreatment of B16F10...

Author(s): Jing-jing Li, Yan-ting Zhang, Dong-yun Ouyang, Li-hui Xu, Hong-bo Mo and Xian-hui He

June 2012

Evaluation of the chemical composition and element analysis of Urtica dioca

This study was conducted to evaluate the chemical composition and elemental analysis of ethyl acetate crude fraction of Urtica dioca. The result obtained shows that all bioactive constituents are present in this fraction of plant. The ethyl acetate fraction was screened which comprises flavonoid (1.88 mg/100 g), alkaloid (1.32 mg/100 g), phenol (0.09 mg/100 g), saponin (1.64 mg/100 g) and tannins (0.8 mg/100 g)....

Author(s): Ahmed A. Abdeltawab, Zain Ullah, , Abdulaziz M. Al-Othman, Riaz Ullah, Iqbal Hussain, Shabir Ahmad and Muhammad Talha

June 2012

Blood glucose levels and pathology of organs in alloxan-induced diabetic rats treated with hydro-ethanol extracts of Allium sativum and Capparis spinosa

Diabetes mellitus (DM) is a growing health concern worldwide. Use of plants for treatment of DM is widely practiced in the Middle East. Garlic (Allium sativum L.) and Capparis spinosa are traditionally used as antidiabetic medications. The present study evaluated the differential effects of ethanol extraction of these plants on the blood glucose concentration and the pathology of pancreatic β-cell mass,...

Author(s): Mohammad Hashemnia, Ahmad Oryan, Ahmad-Reza Hamidi and Adel Mohammadalipour

June 2012

Color Doppler ultrasonography observation of alprostadil injection for diabetes mellitus involved in lower limb vessels

The aim of this study is to observe the clinic result of alprostadil injection for diabetes mellitus patients with lower limb vessels disease which was evaluated by color Doppler ultrasonography. 650 cases of diabetes mellitus with lower limb vessels disease treated by alprostadil injection and followed up by color Doppler ultrasonography to observe the blood flow dynamics inside the vessels and the range of color...

Author(s): Min Zheng