October 2011
The effect of Echinacea on kidney and liver after experimental renal ischemia/reperfusion injury in the rats
The aim of the study is to investigate the effect of Echinacea on kidney and liver against oxidative stress during renal ischemia-reperfusion (I/R) injury, by determining biochemical parameters and evaluating histological examinations. Adult male Sprague-Dawley rats were evaluated in five groups (each group consists of 8 animals). Group 1 (Control; non-ischemic animals); Group 2 (renal I/R injury+saline),...
October 2011
Upregulation effect of glycyrrhizin on secretory component expression in Caco-2 cells
The aim of this study was to investigate whether glycyrrhizin, with steroid hormone-like effects, can upregulate expression of secretory component (SC) in human colonic epithelial Caco-2 and to explore its underlying mechanism. Cultures of Caco-2 were exposed to glycyrrhizin. Free SC in culture supernatants, SC protein, and SC mRNA expression were measured by enzyme-linked immunosorbent assay (ELISA), western blot,...
October 2011
Fluorine-19 nuclear magnetic resonance (19F NMR) as a powerful technique for the assay of anti-HIV drug efavirenz in human serum and pharmaceutical formulations
19F NMR provided a highly specific tool for identification of efavirenz in human serum and pharmaceutical preparations as well as a suitable analytical technique for their absolute quantification. The method is based on the integration of appropriate signals of efavirenz and potassium fluoride, as an internal standard. The proposed method is simple and reliable, but when it is used without any sample pretreatment, there...
October 2011
Anti-depressive activity of Gardeniae fructus and geniposide in mouse models of depression
We evaluated the anti-depressive activity of ethanolic extracts of Gardenia jasminoides Ellis. (GJ EtOH), Gardenia jasminoides Ellis. var. grandiflora Nakai. (GJG EtOH) and geniposide with mouse forced swimming test (FST) and tail suspension test (TST). In addition, we investigated the possible mechanisms of action of anti-depressive effect of geniposide (GPO). The results showed...
October 2011
Muscle and exoskeleton extracts analysis of both fresh and marine crustaceans Procambarus clarkii and Erugosquilla massavensis
Both fresh and marine edible crustaceans Procambarus clarkii and Erugosquilla massavensis, respectively, are now important components of our local aquatic fauna in Egypt that have a small yet growing economic importance in our markets. So, the purpose of the present work was, therefore, to assess the protein, amino acids, fatty acids, minerals, vitamins, protein electrophoresis and dendrogram analysis of...
October 2011
A comparison of the effects of aggressive dose and conventional dose atorvastatin applications on IL-6 and NO levels in patients with acute myocardial infarction
High dose statin medication in acute coronary syndrome cases is a therapy which lowers mortality and morbidity rates. Interleukin-6 (IL-6) is produced in higher amounts in acute myocardial infarction (MI) and facilitates myocardial damage. However, secretion of nitric oxide (NO) is depleted. We aimed to compare the effects of conventional dose (10-40 mg/day) and aggressive dose (80 mg/day) atorvastatin medications on...
October 2011
Some critical effects of starch gel on the granule and tablet properties of a potent herbal extract AM-1
The ability to convert potent herbal medicines into robust tablet will require a good understanding of certain critical factors such as effect of binder concentration on granule particles and tablets properties. In this study, granules of AM-1, a prototype herbal extract has been produced by the wet granulation process of massing and screening using different concentrations of maize starch gel as binder. The effect...
October 2011
Development and validation of RP-HPLC assay for levofloxacin in rat plasma and saliva: Application to pharmacokinetic studies
A new, simple, specific, accurate and precise reversed phase-high performance liquid chromatography (RP-HPLC) method was developed for the determination of levofloxacin in rat plasma and saliva was developed. An HPLC system based on a Phenomenex Luna C18Column (250 × 4.6 mm) and a UV detector (λ = 296 nm) were used. A mixture of Acetonitrile: water (80:20 v/v) adjusted to pH 3.5 by orthophosphoric acid at a...
October 2011
Single and repeated exposure to methamphetamine induces altered sexual behavior in male sailfin molly (Poecilia latipinna Lesueur) (Pisces)
In order to evaluate the effects of methamphetamine on sexual behavior of fish, saltwater-acclimatized male sailfin molly Poecilia latipinna L. (Pisces) adults were exposed to 0.1, 0.5, 1 mg/L methamphetamine (MA) concentrations and were observed for alterations in sexual behavior at 2nd, 5th or 7th exposure days. The overall changes displayed by the subjected fish included different acute and chronic...
October 2011
Relevant influence of promotional tools by pharmaceutical industry on prescribing behaviors of doctors: A cross-sectional survey in Pakistan
Worldwide drug expenditures have been one of the main concerns of health care managers, and its containment is one of the primary goals of health care authorities. The present study was conducted through a cross sectional survey in Pakistan during January to June, 2010 not only to find out the importance and influence of promotional tools used by pharmaceutical industry on prescribing behaviors of doctors/consultants,...
October 2011
A comparative study of cyclo-oxygenase inhibitors on immune response with special reference to Cox-2 inhibitors
The object of this study is to observe the in vivo effect of cyclo-oxygenase-2 (Cox-2) inhibitors on the humoral response after immunization of rabbits with Salmonella typhi antigen. Albino rabbits of either sex were divided into five groups of six animals each and were administered aspirin (100 mg/kg, (BD), p.o), celecoxib (30 mg/kg O.D, p.o), indomethacin (12.5 mg/kg BD, p.o) and etoricoxib (17...
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