African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 8 October, 2012; 6(37)

October 2012

A new relaxant on human corpus cavernosum: Ferulago syriaca root extract

In vitro effects of the extract of Ferulago syriaca used as an herbal medicine in Turkey on human corpus cavernosum were demonstrated. Corpus cavernosum tissue was collected from patients that penile prosthesis implantation had been applied to. Relaxing effect in organ bath was searched for by adding increasing dosages of the extract on tissue strips that were contracted with phenylephrine. It was...

Author(s): Bulent Ozturk, Serap Gur, Maksut Coskun, Murat Kosan, Ceyda S. Erdurak, Gaye Hafez, Umut Gonulalan and Mesut Cetinkaya

October 2012

Components analysis of volatile matter in simethicone by gas chromatography-mass spectrometry

The aims of the present study were to analyze the chemical compositions of volatile matter in simethicone crude drug qualitatively and quantitatively. Gas chromatography-mass spectrum (GC-MS) method was used for the separation and determination of the volatile matter in simethicone. The qualitative analysis of volatile matter components in simethicone with the viscosity of 500-centistokes (cs) was studied by GC-MS,...

Author(s): C. C. Tian, Y. H. Luo, X. Y. Zhao, Q. Chen, M. Luo and L. Y. Luo

October 2012

Antidiabetic and renoprotective effects of water extract of Rosmarinus officinalis in streptozotocin-induced diabetic rat

The antidiabetic effect of water extract of Rosmarinus officinalis was studied in streptozotocin (STZ)-induced diabetes in rats. The efficacy of the extract was also evaluated for protective effects on renal functions and histology in diabetic rats. Oral administration of extract to diabetic rats (200 mg/kg body weight per day for a period of 21 days) produced significant (P <0.001) fall in fasting...

Author(s): Najla O. Ayaz

October 2012

Drug-drug interaction occurring during hospital stay among stroke patients

Drug-drug interactions (DDIs) are defined as two or more drugs interacting in such a manner that the effectiveness or toxicity of one or more drugs is altered. DDI in patients receiving multiple drug therapy is a major concern. Such interactions may lead to an increased risk of hospitalization and higher health care costs. The present study was designed to assess the incidence and pattern of DDIs in hospitalized stroke...

Author(s): Subash Vijayakumar, Ravi kanth S, Ayesha Siddiqua and Dheeraj Kumar G

October 2012

Increased level of type I Interferon (IFN) during type I diabetes (T1D) induces apoptosis in spleen-homing T cells

Type I diabetes (TID) is an autoimmune disease characterized by abnormalities in the defense mechanisms against a variety of infectious agents. Susceptibility to infections occurring in diabetic individuals is attributed to the decrease in the number of lymphocytes, which is probably a clinical consequence of the occurrence of apoptosis described in diabetes. TID is associated with increased cytokines that dampen...

Author(s): Heba M. Saad Eldien, El-Elaimy IA, Ibrahim HM, Badr Mohamed Badr and Gamal Badr,

October 2012

Polyporus umbellatus polysaccharides ameliorates carbon tetrachloride-induced hepatic injury in mice

The purpose of this study was to investigate the hepatic protective function and potential mechanism of Polyporus umbellatus polysaccharides (PPS) to hepatic injury. Previous study has revealed that PPS possesses antitumor and immunomodulatory activities. In this study, we further demonstrate the protective function of PPS using carbon tetrachloride (CCl4)-induced hepatic injury in mouse model. The effects of...

Author(s): Kang Peng, Lv Shu Lan, Wang Xiao Yan, Sun Li Jie, Yu Jian Wu, Zhao Yong Hua and  Li Shu-Chen

October 2012

Antioxidant and antibacterial activity of the extracts of Echinophora platyloba D.C

Hydroalcholic and aqueous extracts of Echinophora platyloba D.C were screened for their possible antioxidant activity by β-carotene-linoleic acid and antibacterial effects using the microdilution method for Alcaligenes faecalis, Serratia marcescens, Providencia rettgeri andListeria monocytogenes. Total phenols, flavonols and flavonoids were determined colorimetrically. In the...

Author(s): Reza Sharafati-chaleshtori, Mahmoud Rafieian-kopaei, Seifollah Mortezaei, Ali Sharafati-chaleshtori and Elham Amini

October 2012

Promotion of all-trans retinoic acid (ATRA)-induced differentiation of acute promyelocytic leukemia cells by Bufalin

All-trans retinoic acid (ATRA) has been shown as a promising agent for the treatment of acute promyelocytic leukemia (APL). However, the clinical application of ATRA is limited by the resistance of APL to ATRA-induced differentiation. Bufalin is a steroid isolated from Chan’su and could induce leukemia cell differentiation. This study is aimed to determine whether bufalin treatment could promote ATRA-induced...

Author(s): Zhitu Zhu, Yunpeng Liu, Kezuo Hou, Enze Li, Hongzhi Sun, Ying Wang, Zhenghua Wang, Xiaomei Liu and Qingjun Wang

October 2012

Protection of rat fetuses by quercetin against caffeine-induced cleft palate

Caffeine at high doses is a known rodent teratogen and it induces limb malformations along with cleft palate in various strains of rats and mice. The teratogenic effects of some drugs can be prevented by the application of antioxidant drugs and stimulation of the maternal immune system. Also, there are some evidence that quercetin is an antioxidant. Therefore, in this study, the prophylactic effect of quercetin on...

Author(s): Mahmood Khaksary Mahabady and Hossein Najafzadeh Varzi

October 2012

Preconditioning effect mediated by heme oxygenase-1 (HO-1) is lung-protective in a rat model of limb ischemia and reperfusion

The preconditioning with short limb ischemia has been shown to be protective to prevent tissue damage caused by ischemia. Numerous underlying factors have been suggested to be important in these processes, including heme oxygenase-1 (HO-1). This study investigated the potential protective mechanism mediated by HO-1 for lung protection in a rat model of limb ischemia and reperfusion. The results showed that HO-1 was...

Author(s): Li-hua Fan, Xiang-dong Xu, Xiang-hong Lu, Xin Han, Hong Cao, Qing-quan Lian, Wei Zhou and Jun Li