June 2011
Effect of ulinastatin preconditioning on the expression of hemeoxygenase-1 in limb ischemia reperfusion lung injury in rats
To investigate the role of HO-1 in ischemic preconditioning and pharmacological preconditioning by ulinastatin in attenuating remote lung injury in rat model of lower limb ischemia reperfusion. Sixty four male SD rats were randomly divided into four groups: Sham operation group, ischemia and reperfusion group, ischemia preconditioning group (IPR), ulinastatin preconditioning group (UTI). The animals were deeply...
June 2011
The effect of fenugreek on the bioavailability of glibenclamide in normal beagle dogs
Fenugreek (Trigonella foenum-graceum) is an herbal medicine widely used in the traditional medicine to alleviate many diseases including diabetes. Many studies proved its efficacy in reducing blood sugar in diabetic patients. Concurrent administration of fenugreek and glibenclamide may affect bioavailability of glibenclamide. For this reason this study was designed to clarify effect of fenugreek ingestion on...
June 2011
Effect of aspartame on some oxidative stress parameters in liver and kidney of rats
Aspartame is one of the most widely used artificial sweeteners in over 90 countries worldwide. It is a highly intensity sweetener added to a large variety of food, most commonly found in low calorie beverages, desserts and table top sweeteners added to tea or coffee. The present study examined whether the daily oral administration of ASP (40 mg/kg) for 2, 4 and 6 weeks induce oxidative stress in the liver and kidney of...
June 2011
Effects of competition term trainings on leptin values of female judokas
The purpose of this study was to measure serum leptin and insulin levels of 16 female judokas between the ages of 16 and 19 in the Turkish national judo team and to compare the values before and after 6-week training program height and weight values of athletes participated in the study were measured before and after the training period. The percentage of body fat was measured by Holtain brand skin fold and body mass...
June 2011
Evaluation of antioxidant and fertility effects of Digera muricata in male rats
Treatment of carbon tetrachloride (CCl4) 1 ml/kg b.w. (10% in olive oil) to Sprague-Dawley male rats once a week for 16 weeks caused a significant increase in serum level of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), cholesterol, low density lipoprotein (LDL), direct bilirubin, total bilirubin, estradiol and prolactin; whereas suppressed level of...
June 2011
Therapeutic effect of petroleum ether extract from Semen cuscutae against β-estradiol 3-benzoate induced kidney-yang deficiency in mice
This study aimed to investigate the ameliorative effect of the petroleum ether extract ofSemen cuscutae (SCPEE) on β-estradiol 3-benzoate (EB) induced kidney-yang deficiency (KD) by using an animal model. This model was established by daily intraperitoneal injection of EB (4 mg/kg) to ICR male mice for 15 days. To evaluate the SCPEE effect, after the first EB injection, the mice were orally administrated daily...
June 2011
Rapid screening for 61 central nervous system drugs in plasma using weak cation exchange solid-phase extraction and high performance liquid chromatography with diode array detection
Rapid and accurate screening for toxicants/chemicals in a broad range is an important element in systematic toxicological analysis (STA). Herein, we report a novel method for the rapid screening of 61 central nervous system (CNS) drugs in plasma, using a solid-phase extraction (SPE) column termed, weak cation exchange (WCX) and high performance liquid chromatography with a diode array detector (HPLC-DAD). The SPE column...
June 2011
Anti-oxidative effects of citro flavonoids on spermatogenesis in rat
Citrus fruits have long been recognized as containing valuable sources of important nutrients which are biologically active in humans. Citrus fruits, such as oranges, contain compounds called phytochemicals that can be included into three major groups: the flavonoids, limonoids and carotenoids. The flavonoids are a group of benzopyran derivatives which occur widely in plants. The flavonoids typically consist of a...
June 2011
The effects of tobacco smoke generated from cigarettes exposed to pulsed electromagnetic field in the rat
In this study, we have investigated the toxic effects of tobacco smoke obtained from cigarettes treated in pulsed electromagnetic field in the rat. The treatment of cigarettes was accomplished before the initiation of animal studies after exposure of standard cigarettes to pulsed electromagnetic irradiation of low power (>10-7W) and wide frequency spectrum (30 Hz to 300 GHz) during 24 h according to the technology...
June 2011
Determination of enantiomeric compositions of ibuprofen by infrared spectrometry with catalytic amount of simple chiral recognization reagent
Catalytic amount of cheap chiral recognition reagent (quinine) combined with chemometric and infrared spectroscopy (IR) was used for quick and accurate determination of the enantiomeric compositions of ibuprofen. First of all, full spectrum was used as the input variable of partial least regression (PLS) to establish the calibration model, after which a good prediction rate of the average error of 4.65% was obtained....
June 2011
The effects of carotid baroreceptor stimulation on blood pressure variability in young male athletes and non-athletes
The purpose of this study was to investigate the effects of carotid baroreceptor (BR) stimulation on blood pressure changes in young male volleyball players and non-athletes. Twenty five young male volleyball players and twenty-five young male non-athletes were recruited for voluntary participation in the present study. A neck suction device (Ekberg,s model) was used for stimulation of carotid baroreceptor. In this...
June 2011
Analysis of silymarin in the seeds of white and blue capitulum of Silybum marianum plants
Silybum marianum is a wild medicinal plant containing silymarin, which is a known drug, used as the hepatoprotective agent. S. marianum growing in different areas of NWFP were collected and analyzed for the silymarin and oil contents. In all the samples analyzed for the silymarin, high yield was found in the sample collected from Swat district (3.85%) while high yield of oil was recorded in the sample...
June 2011
Phytochemicals screening and antimicrobial activities of selected medicinal plants of Khyberpakhtunkhwa Pakistan
The study was carried out to assess the phytochemical and antimicrobial bioassay of five medicinal plants, Lepidium sativum, Nerium oleander, Ranunculus repens,Tecoma stans and Urtica dioca. These plants are traditionally used as medicine in the Northwest Pakistan, therefore it is necessary to identify and estimate their alkaloid,...
June 2011
Antioxidant and antibacterial constituents from Morus nigra
The objective of this study was to isolate and characterize the constituents of the localMorus nigra L. (Black mulberry), to compare its constituents with other studied Mulberries and to evaluate its anti-oxidative and anti-bacterial activities. The isolated compounds were identified by comparison of spectral data (UV, IR, MS and NMR) with literature values. The stem bark and wood of M. nigra yielded...
June 2011
Preventive effect of Rhododendron arboreum on cardiac markers, lipid peroxides and antioxidants in normal and isoproterenol-induced myocardial necrosis in rats
This study was designed to investigate the preventive effect of ethanolic extract ofRhododendron arboretum (ERA) against isoproterenol-induced myocardial ischemia in rat myocardium. Wister rats were pretreated with ERA (100, 250, 500 mg kg-1) orally for 42 days and then intoxicated with isoproterenol (ISO, 150mg/kg body weight, s.c. for 2 days). MI induced in rats by subcutaneous injection of ISO-(150 mg/kg body...
June 2011
A systematic review of the adverse effects of tacrolimus in organ transplant patients
Tacrolimus has been the drug of choice for prevention of graft rejection following organ transplantations. This systematic review and meta-analysis [UiTM1] was conducted to evaluate the efficacy of tacrolimus in organ transplantation. Publication in English of randomized clinical trials, which used tacrolimus to prevent graft rejection in adult patients were included in this analysis. Articles were searched from PubMed,...
June 2011
Volatile constituents and anti candida activity of the aerial parts essential oil of Dittrichia graveolens (L.) Greuter grown in Iran
The aims of present study were to analysis of chemical compositions and evaluate anti-Candida activity of Dittrichia gravolence essential oil. The composition of the hydrodistilled essential oil from aerial parts of D. graveolens (L.) Greuter were grown in Iran investigated by gas chromatography-mass spectroscopy (GC/ MS). The major components, among the identified 22, were 1,8 Cineol (54.89%),...
June 2011
Antioxidant effect of the Egyptian freshwater Procambarus clarkii extract in rat liver and erythrocytes
The present study aims to evaluate the curative activity of freshwater crustacean extract (FCE) from freshwater crayfish Procambarus clarkii and silymarin on oxidative stress induced by carbon tetrachloride (CCl4) in rat liver and erythrocytes. The degree of treatment in this activity has been measured by using biochemical parameters such as serum aspartate aminotransferase (ASAT), alanine aminotransferase...
June 2011
Experimental model for safe in vitro- and in vivo-influence of internal and external factors of cell differentiation
Gene transfer in laboratory-cultivated mouse embryonic stem cells (mESCs) was made by appropriate recombinant DNA-constructs. Electrophoretic profiles of genetic material from wild type on oncogene Dcn1 and “knock-down” on it inbred experimental mice differed not only in it, but also in tumor-suppressor gene HACE1 between both categories of laboratory rodents. The results obtained were compared with...
June 2011
Effect of Urtica dioica leaf extract on activities of nucleoside diphosphate kinase and acetyl coenzyme, a carboxylase, in normal and hyperglycemic rats
Urtica dioica has been shown to have capability of reducing blood glucose through enhancing insulin secretion. The aim of this study was to assess in vivo and in vitroeffects of aqueous and alcoholic extracts of U. dioica leaves on activities of Acetyl coenzyme A carboxylase (ACC), Nucleoside diphosphate kinase (NDPK) and insulin level and serum glucose concentration. The experimental...
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