International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 534

Full Length Research Paper

Ameliorative effects of α-tocopherol on cypermethrin induced oxidative stress and lipid peroxidation in Wistar rats

Rajinder Raina
  • Rajinder Raina
  • Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, R.S. Pura, Jammu-181102, J&K, India.
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Pawan Kumar Verma
  • Pawan Kumar Verma
  • Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, R.S. Pura, Jammu-181102, J&K, India.
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N. K. Pankaj
  • N. K. Pankaj
  • Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, R.S. Pura, Jammu-181102, J&K, India.
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Vinay Kant
  • Vinay Kant
  • Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, R.S. Pura, Jammu-181102, J&K, India.
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  •  Accepted: 21 August 2009
  •  Published: 30 September 2009

Abstract

Environmental contamination of pyrethroids is responsible for increasing oxidative stress in man and animals. The present study was aimed to investigate the ameliorative effects of α-tocopherol on different stress parameters in rats. Significant (p<0.05) increased catalase activity in cypermethrin treated rats is maintained normal by the supplementation of α-tocopherol. Significantly reduced (p<0.05) SODs and GSH-Px activity by cypermethrin treated rats and activity of these enzymes were comparable to control animals by α-tocopherol supplementation. Significantly reduced GSH and increased (p<0.05) lipid peroxidation were observed in both groups, cypermethrin alone and along with the α-tocopherol treated groups. Observations from the present study suggest that α-tocopherol supplementation plays a protective role in cypermethrin induced oxidative stress in rats and linseed oil is not suitable as a vehicle for α-tocopherol.

Key words: Cypermethrin, oxidative stress, α-tocopherol, Wistar rats.

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