International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 531

Full Length Research Paper

Immunoactive property of acute and subacute administration of high dilution of Gelsemium sempervirens L., Histaminum and Poumon histamine

Hassan Rammal
  • Hassan Rammal
  • Lebanese University, Doctoral School of Science and Technology, Research Platform for Environmental Science (PRASE), Lebanon.
  • Google Scholar
Rachid Soulimani
  • Rachid Soulimani
  • Neurotoxicologie Alimentaire et Bioactivié, UR AFPA, Université Paul Verlaine de Metz-INPL-INRA, BP 4102, 57040 Metz, France.
  • Google Scholar

  •  Accepted: 02 September 2010
  •  Published: 01 January 2011



Anxiety is associated with subjective distress and many harmful physiological effects including oxidative stress, immunodepressive effect, and an increase in blood pressure. Anxiety is also implicated in a number of psychiatric disorders. The objective of this work was to study the protective property of homeopathic drugs on immunodepression caused by high anxiety level by evaluating the immunological effect of both acute and subacute intraperitoneally administration of high dilutions (9 CH, 15 CH and 30 CH) of Gelsemium sempervirens L., Histaminum and Poumon histamine in mice with contrasting level of anxiety evaluated in the light/dark choice test. Our results showed that these homeopathic drugs at different dilutions exert an important immunotrope effect on the cellular (granulocytes, monocytes, total lymphocytes, TCD4+, TCD8+ and NK cells) and humoral (immunoglobulins A, E and G) immunity in anxious mice.


Key words: Anxiety, Gelsemium sempervirens L., HistaminumPoumon histamine, light/dark choice test, cellular and humoral immunity.