Full Length Research Paper
Abstract
In search for potential antitumor drug candidates, a series of thiosemicarbazide derivatives were prepared via 4-(2-pyridyl)-3-thiosemicarbazide with phenyl isothiocyanate, benzoyl isothiocyanate, phenyl isocyanate and 4-pyridyl isothiocyanate. Effects of the synthesized compounds were tested using in vitro growth of a transplantable murine tumor cell line (Ehrlich Ascites Carcinoma) and in vivo-induced hepatocellular carcinoma (HCC) were studied. 1-(amino N-(pyridin-3yl)methanethiol-4-(pyridin-2-yl) thiosemicarbazide (H2PPY) has remarkably decreased the viable ascitic cell count as indicated by trypan blue dye exclusion assay. This compound prolonged the lifespan of Ehrlich Ascites Carcinoma (EAC) bearing-mice. Tumor inhibitory of this compound was demonstrated by significant improvement in blood picture (hemoglobin, RBC and WBC). The in vivo studies for H2PPY in HCC on rats showed a substantial improvement on both biochemical and histopathological parameters in comparison to non-treated HCC rats. The obtained data of the tested compound exhibited minimal adverse effects on the treated animals as compared to those of the untreated control groups.
Key words: Thiosemicarbazide derivatives, EAC, HCC, antitumor activity.
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