International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 534

Full Length Research Paper

Penta- and hexapeptide sharing between HPV16 and Homo sapiens proteomes

Darja Kanduc
  • Darja Kanduc
  • Department of Biochemistry and Molecular Biology, University of Bari, Italy.
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  •  Accepted: 21 August 2009
  •  Published: 30 September 2009

Abstract

The primary sequence of the HPV16 proteome was analyzed for penta- and hexa-peptide sequences shared with human proteins. The following data were obtained: 1) HPV16 andHomo sapiens proteomes share thousands of identical peptide motifs; 2) the overlaps are inter-dispersed among human proteins involved in fundamental housekeeping functions as well as crucial processes such as cell growth, differentiation and neurosensory regulation.The data are discussed in relationship to the potential cross-reactivity risk of an HPV16 vaccine.

Key words: Similarity analysis, sequence-sequence peptide matching, viral versus human proteome over-lapping, vaccine-related cross-reactions

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This article is published under the terms of the Creative Commons Attribution License 4.0

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