To analyze population pharmacokinetics of Propofol in Females in Indian patients after single bolus dose of Propofol using WINNONLIN program.Population pharmacokinetics of Propofol in females was investigated in Indian subjects in 12 elective surgical patients following single bolus dose of 2mg/kg propofol. Total of 168 samples were estimated by High performance liquid chromatography (HPLC) and pharmacokinetic parameters were derived using WINNONLIN (5.2). The effect of demographic characters of the study population on pharmacokinetic parameters was investigated.Three compartment model was used to describe the pharmacokinetic data of Propofol in Indian females. Initial volume of distribution (V1) clearance (Cl) and steady state volume of distribution (Vdss) was 13.6 Â± 2.8 L, 1.09 Â± 0.41 L/min and 75Â± 53.2 L respectively. Body weight best described the volume of central compartment (V1) as well as elimination clearance (P<0.01) in Indian Female subjects.Pharmacokinetics of Propofol in females in Indian subjects show lower volume of distribution and clearance as compared to the western data.. Body weight best describes the V1 in Indian Females.
Keywords: Anaesthetics , Propofol, Pharmacokinetics, volume of distribution