April 2009
Pharmacogenomics: benefits of personalized medicines
Pharmacogenomics is a science that examines the inherited variations in genes that dictate drug response and explores the ways these variations can be used to predict whether a patient will have a good, bad, or no response at all to a drug. It refers to the general study of all of the many different genes that determine drug behavior. It could also guide companies in designing clinical trials that would more...
April 2009
An unusual cause of acute tympanic membrane perforation: a case report
This is a case report of a 26 – year old lady who presented in the Accident and Emergency Department of our hospital with complaints of sudden onset of right otalgia, tinnitus and loss of hearing which she claimed started at about 12:30 h after vigorous kissing incident. The tympanic membrane was ruptured. She was managed conservatively with oral antibiotics with spontaneous and complete healing of the perforated...
April 2009
Methotrexate-induced toxic epidermal necrolysis: a case report
Methotrexate (MTX) is a folic acid antagonist that inhibits the enzyme dihydrofolate reductase resulting in decreased cell levels of tetrahydrofolate. Adverse cutaneous reactions to MTX are usually dose-related and have been mainly reported in patients receiving extremely large doses of chemotherapy. Toxicity can affect multiple organ systems including bone marrow, liver, intestinal tract, kidneys, lungs, skin, and...
April 2009
Intraoperative low molecular weight heparin and postoperative bleeding
A case of postoperative bleeding associated with low molecular weight heparin (LMWH) administration is reported. A literature search suggests that perioperative bleeding can be as high as 11% when LMWH is administered intraoperatively. When administered 6 h postoperatively, LMWH does not signi-ficantly increase the risk of bleeding whilst retaining efficacy for venous thromboembolism prop-hylaxis. Although LMWH has not...
April 2009
Efficacy of some antibacterial agents on Staphylococcus aureus isolated from various burn cases
The present study aimed to determine the major bacterial types from various burn cases and a study of antibacterial activity of plant extracts against Staphylococcus aureus isolated from burn cases in comparison with standard antibiotics.A total of 35 specimens were collected from burned patients (both sex, various degrees of burns) in burns unit of Al-Basrah General Hospital and Alsader Teaching...
April 2009
The influence of mode of delivery on the levels of high-sensitivity C - reactive protein determined in umbilical cord blood
Data suggest that the fetus responds to chronic hypoxia by higher umbilical cord blood high-sensitive CRP concentrations. In order to evaluate the effects of acute hypoxia on fetus, cord blood high-sensitive CRP concentrations according to the delivery mode were compared. High-sensitive CRP concentration was measured by an immunonephelometric method in umbilical cord blood samples from 45 newborns born by...
April 2009
Bone tumors at Addis Ababa University, Ethiopia: agreement between radiological and histopathological diagnoses, a -5-year analysis at Black-Lion Teaching Hospital
The study aims at looking into clinical, radiological and histopathological agreement in diagnosing bone tumors and elaborates the spectrum of bone tumors referred to Black-Lion Hospital, BLH. All bone tumor patients, who presented to all the three departments at BLH between the study periods of December 2003 – March 2008 were recruited. the radiological and histopathological diagnoses made were categorized...
April 2009
Aminothienoandrostane: novel promising anti-tumor agent
The sensitivity of liver to chemotherapy provides the basis of novel investigational treatment. An amino thienoandrostane derivative was synthesized and tested in vitro for anti-tumor activity against heapto-ma cell lines (HepG2) using MTT assay. Also the in vivo anti-tumor activity was evaluated against Ehrlich ascites carcinoma (EAC). After 24 h of tumor inoculation, the tested compound was...
April 2009
Insulin resistance and blood pressure in Nigerian type 2 diabetic patients
Considerable interest has been generated on the possible role of insulin resistance (IR) in the etiology and sustenance of hypertension among type-2 diabetic subjects. There is paucity of data on this relationship on African diabetic patients. The aim of this study is to show the relationship between homeostasis model assessment (HOMA) derived insulin resistance (IR) scores and blood pressure among type-2 diabetic...
April 2009
Anthropometric comparison of nasal indices between Andoni and Okrika tribes of Rivers State, Nigeria
A comparative study on Nasal Index was carried out on subjects from Andoni and Okrika tribes of Rivers State in the Niger Delta region of Nigeria. Four hundred individuals were randomly selected from each tribe comprising 200 males and 200 females, respectively. The ages of the subjects ranged from 21-30 years. The height of the nose (NH) and the breadth of the nose (NB) were measured for each subject using a sliding...
April 2009
Performance of syphilis serology in students of Ambrose Alli University, Ekpoma, Nigeria
5 ml of venous blood was aseptically collected from 112 consenting, apparently healthy students of Ambrose Alli University Ekpoma, Nigeria. The enrollees were 62 males and 50 females (age range, 15 – 44 years). The Rapid Plasma Reagin (RPR) and Immunochromatographic tests (Spodex Diagnostic Company) were used to screen and confirm the presence of syphilitic antibodies in their serum and plasma. Out of the 112...
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