March 2013
Blockade of Akt/mTOR pathway and enhancement of histone acetylation by PHI to induce cells apoptosis in prostate cancer PC3 cells
Mammalian target of rapamycin (mTOR) has merged an important therapeutic target for cancers. Our object is to demonstrate that phenyhexyle isothiocyanate (PHI), a synthetic isothiocyanate, blocked Akt/mTOR signaling in prostate cancer PC3 cell line, in addition to inhibited histone deacetylase to induce cell apoptosis. Apoptotic cells were measured by TUNEL assay. Histone acetylated H3, H4 and the protein of Akt...
March 2013
Genetic diversity evaluation of Paraschistura bampurensis (Nikolskii, 1900) in Shapour and Berim Rivers (Iran) using microsatellite markers
Paraschistura bampurensis is one of the species of genus Paraschistura. It is distributed in Iran and Pakistan freshwater. This paper reports a study carried out on genetic diversity and population structure of P. bampurensis in Shapour and Berim river basins, Iran. 100 samples of 50 fish each were collected from each river and were used. Microsatellite markers have been increasingly used in...
