Journal of
General and Molecular Virology

  • Abbreviation: J. Gen. Mol. Virol.
  • Language: English
  • ISSN: 2141-6648
  • DOI: 10.5897/JGMV
  • Start Year: 2009
  • Published Articles: 37

Full Length Research Paper

No xenotropic murine leukemia virus-related virus (XMRV) detected in Swedish monozygotic twins discordant for chronic fatigue

  Patrick F. Sullivan, Franzcp1,2, Tobias Allander3, Cecilia Lindau3, Kristina Fahlander3, Andreas Jacks2, Birgitta Evengård4, Nancy L. Pedersen2 and Björn Andersson5*
  1Department of Genetics, University of North Carolina at Chapel Hill, NC, USA. 2Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 3Laboratory for Clinical Microbiology, Department of Microbiology, Tumor and Cell Biology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. 4Department of Clinical Microbiology, University of Umeå, Umeå, Sweden. 5Department of Cell and Molecular Biology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Email: [email protected]

  •  Accepted: 05 September 2011
  •  Published: 31 October 2011



The recent debate regarding the possible involvement of xenotropic murine leukemia virus-related virus (XMRV) in chronic fatigue syndrome (CFS) in humans has been intense due to the conflicting results from different studies and the unclear origin of the XMRV virus. In this study, we have addressed this issue by screening 47 pairs of monozygotic twins discordant for CFS using a sensitive PCR assay. The results are clearly negative for all samples. This is consistent with studies showing no evidence for the involvement of XMRV in CFS and supports the possibility that previous positive studies could be caused by laboratory artifacts.
Key words: Chronic fatigue syndrome (CFS), idiopathic chronic fatigue, infectious disease, xenotropic murine leukemia virus-related virus (XMRV), monozygotic twins