Journal of
Toxicology and Environmental Health Sciences

  • Abbreviation: J. Toxicol. Environ. Health Sci.
  • Language: English
  • ISSN: 2006-9820
  • DOI: 10.5897/JTEHS
  • Start Year: 2009
  • Published Articles: 218

Full Length Research Paper

The amelorative effect of L-arginin and omega-3 fatty acid against sodium valproate induced hepatotoxicity

Dalia M. Amin
  • Dalia M. Amin
  • Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Egypt.
  • Search for this author on:
  • Google Scholar
Marwa T. Abaza
  • Marwa T. Abaza
  • Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Egypt.
  • Search for this author on:
  • Google Scholar
Walaa M. Sarhaan
  • Walaa M. Sarhaan
  • Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Egypt.
  • Search for this author on:
  • Google Scholar
Amany I. Ahmed
  • Amany I. Ahmed
  • Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Egypt.
  • Search for this author on:
  • Google Scholar
Amr A. Moustafa
  • Amr A. Moustafa
  • Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Egypt.
  • Search for this author on:
  • Google Scholar


  •  Received: 15 May 2018
  •  Accepted: 20 July 2018
  •  Published: 31 July 2018

Abstract

Sodium valproate (VPA) used in epilepsy and has hepatotoxic effect in mammals. This work is to assess the role of L-arginin and omega-3 fatty acid against VPA oxidative stress on liver. This study was carried out on 70 rats divided into 7 groups each of 10 rats treated orally once daily 6days/ week; Group I (control), Group II ( L-arginin): each rat was received 300 mg/kg L-arginin, Group III (omega-3): each rat received 300 mg/kg omega-3, Group IV (VIA): Each rat received  400 mg/kg VPA. Group V (VPA and L-arginin): Each rat received the previous doses. Group VI (VPA and omega-3): as before. Group VII (VPA, L-arginin and omega-3 group): as before. There was a significant increase in the mean values of AST, ALT, ALP and TBL in VPA treated group. Upon supplementation with L-arginin or omega-3 to VPA treated rats there was a significant decrease in the mean values of AST, ALT, ALP and TBL. Microscopic examination of liver section of VPA treated rat revealed vacuolated hepatocytes, focal necrosis, and enlarged portal tract. VPA toxicity induced severe liver damage in rats, and administration of either L-arginin or omega-3 protecting liver tissues.

Key words: L-arginin, omega-3 and sodium valproate.

 

Copyright © 2025 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

Back to Vol. 10 No. 4
Back to articles
SUBSCRIBE TO RSS
SUBMIT MANUSCRIPT
CONFERENCES