Full Length Research Paper
References
|
Abd El-Baky A, Abdullah A, Abd-El Hay E (2009). Amelioration of iron-overload adverse effect by iron chelator in rats. Journal of Applied Sciences Research 5:1155-1162. |
|
|
AbdElkader A, Aly F (2015). Protective Effect of Melatonin Against Iron Overload-Induced Toxicity In Rats. International Journal of Pharmacy and Pharmaceutical Sciences 7(9):116-121. |
|
|
Ahmadi M, Dehghan G, Hosseinpourfeizi A, Dolatabadi N, Kashanian S (2011). Preparation, characterization, and DNA binding studies of water-soluble quercetin–molybdenum (VI) complex. DNA and Cell Biology 30(7):517-523. |
|
|
Ali M, Gomaa M, Shalby S, Mohammed Z (2017). Study of chronic toxic effect of deltamethrin and dimethoate on brain of adult male albino rats. Zagazig Journal of Forensic Medicine 15(1):29-46. |
|
|
Anderson J (2007). Mechanisms of iron loading and toxicity. American Journal of Hematology 82:1128-1131. |
|
|
Ayer A, Mario M, Sandro A (2014). Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal Oxidative. Med. Cell. Longevity, Article ID 360438, 31. |
|
|
Baccan M, Chiarelli-Neto O, Pereira S, Espósito P (2012). "Quercetin as a shuttle for labile iron," Journal of Inorganic Biochemistry 107(1):34-39. |
|
|
Bancroft D, Stevens A (1996). Theory and Practice of Histological Techniques. (4thEd.).Churchill Livingstone Press, Edinburgh, London, Melbourne, New York pp. 99-112. |
|
|
Barcelos R, Grotto D, Serpelon M, Angeli P, Rocha A, de Oliveira Souza C, Vicentini T, Emanuelli T, Bastos K, Antunes M, Knasmüller S, Barbosa J (2011). Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats. Archives of Toxicology 85:1151-1157. |
|
|
Berdoukas V, Nord A, Carson S, Puliyel M, Hofstra T, Wood J, Coates D (2013). Tissue iron evaluation in chronically transfused children shows significant levels of iron loading at a very young age. American Journal Of Hematology 88:283-285. |
|
|
Beutler E (2006). Hemochromatosis: genetics and pathophysiology. Annual Review of Medicine 57:331-347. |
|
|
Bu T, Mi Y, Zeng W, Zhang C (2011). Protective effect of quercetin on cadmium-induced oxidative toxicity on germ cells in male mice. Anatomical Record 294:520-526. |
|
|
Bureau G, Longpre F, Martinoli G (2008). Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. Journal of Neuroscience Research 86:403-410. |
|
|
Chan T, Lin C, Chuang H, Shiau J, Liao W, Yeh L (2014). "Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte Dna Damage and Plasma Lipid Peroxidation Induced by Tsa in Vivo," BioMed Research International. |
|
|
El-Maraghy A, Rizk M, El-Sawalhi B (2009). Hepatoprotective potential of crocin and curcumin against iron overload-induced biochemical alterations in rat. African Journal of Biochemistry Research 3:215-221. |
|
|
El-Nekeety A, Abdel-Azeim H, Hassan M, Hassan S, Aly E, Abdel-Wahhab A (2014). "Quercetin inhibits the c ytotoxicity and oxidative stress in liver of rats fed aflatoxin-contaminated diet," Toxicology Reports 1:319-329. |
|
|
Elseweidy M, Abd El-Baky E (2008). Effect of dietary iron overload in rat brain: oxidative stress, neurotransmitter level and serum metal ion in relation to neurodegenerative disorders. Indian Journal of Experimental Biology 46(12):855-858. |
|
|
El-Sheikh A, Ameen H, AbdEl-Fatah S (2018). Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine. International Journal of Toxicology 2018. |
|
|
Fairbairn W, Olive L, O'Neill L (1995). The comet assay: A comprehensive review. Mutation Research 339:37-59. |
|
|
Frey A, Reed H (2012). The ubiquity of iron. ACS Chemical Biology 7:1477-1481. |
|
|
Gerates L, Moonen J, Brauers K, Wouters M, Bast A, Hageman J (2007). Dietary flavones and flavonols are inhibitor of poly (ADP-ribose) polymerase-1 in pulmonary epithelial cells. Journal of Nutrition 137:2190-2195. |
|
|
Gholampour F, Ghiasabadi B, Owji M, Vatanparast J (2017). The protective effect of hydroalcoholic extract of Ginger (Zingiber officinale Rosc.) against iron-induced functional and histological damages in rat liver and kidney. Avicenna Journal of Phytomedicine 7(6):542-553. |
|
|
Goodman S, Gilman A (2006). The Pharmacological Basis of Therapeutics.11th edition. New York: McGraw-Hill. |
|
|
Halliwell B, Gutteridge M (1990). Role of free radicals and catalytic metal ions in human disease: An overview.Methods in Enzymology186: 1-85. |
|
|
Hametner S, Wimmer I, Haider L, Pfeifenbring S, Br€uck W, Hans H (2013). Iron and Neurodegeneration in the Multiple Sclerosis Brain. Annals of Neurology 74(6):1-14. |
|
|
Horniblow D, Henesy D, Iqbal H, Tselepis C (2017). Modulation of iron transport, metabolism and reactive oxygen status by quercetin-iron complexes in vitro. Molecular nutrition and food research 61(3):1600692. |
|
|
Horta N, Kahl F, Sarmento S, Nunes S, Maglione R, Andrade M FF, Da Silva J (2016). Protective effects of acerola juice on genotoxicity induced by iron in vivo Molecular genetics. Biology 39(1):122-128. |
|
|
Howerton E, Tarzami T (2017). Tumor Necrosis Factor-Alpha and Inflammation-Mediated Cardiac Injury. Journal of Cell Science and Therapy 8:268. |
|
|
Institute of laboratory animals' resources, Commission on life sciences, National research council (1996). Guide for the care and use of laboratory animals. National Academy Press. |
|
|
Jammal M, Da silva A, Filho M, Côbo C, Adad J, Murta C, Nomelini S (2015). Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms. Oncology Letter 9(2):979-983. |
|
|
Joslin J (2009): Blood collection: Techniques in exotic small mammals. Journal of Exotic Pet Medicine 18(2):117-139. |
|
|
Kehrer P (2000). The Haber–Weiss reaction and mechanisms of toxicity. Toxicological 149:43-50. |
|
|
Kell B (2010).Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples," Archives of Toxicology 84(11):825-889. |
|
|
Kempuraj D, Madhappan B, Christodoulou S, Boucher W, Cao J, Papadopoulou N, Cetrulo L, Theoharides C (2005). Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. British Journal of Pharmacology 145:934-944. |
|
|
Khan F, Niaz K, Maqbool F, Hassan H, Abdollahi M, Kalyan C, Venkata N, Nabavi M, Bishayee A (2016). A Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update Nutrients 8(9):529. |
|
|
Kleemann R, Verschuren L, Morrison M, Zadelaar S, van EJ, Wielinga, Y, Kooistra T (2011). Anti-inflammatory, anti-proliferative and antiatherosclerotic effects of quercetin in human in vitro and in vivo models. Atherosclerosis 218:44-52. |
|
|
Kohgo Y, Ikuta K, Ohtake T, Torimoto Y, Kato J (2008). Body iron metabolism and pathophysiology of iron overload. International Journal of Hematology 88(1):7-15. |
|
|
Koracevic D, Koracevic G (2001). Total antioxidant capacity. Journal of Clinical Pathology 54:356-361. |
|
|
Kozlowski H, Janicka-Klos A, Brasun J, Gaggelli E (2009). Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation). Coordination Chemistry Reviews 253:2665-2685. |
|
|
Kremastinos T, Farmakis D, Aessopos A, Hahalis G, Hamodraka E, Tsiapras D (2010). Betathalassemia cardiomyopathy: history, present considerations, and future perspectives. Circulation Heart Failure 3(3):451-458. |
|
|
Kulaksiz H, Fein E, Redecker P, Stremmel W, Adler G, Cetin Y (2008). Pancreatic b-cells express hepcidin, an iron-uptake regulatory peptide. Journal of Endocrinology 197:241-249. |
|
|
Lebda M (2014). Acute Iron Overload and Potential Chemotherapeutic Effect of Turmeric in Rats. International Journal of Pure and Applied Bioscience 2(2):86-94. |
|
|
Leopoldini M, Sandro C, Marisosa T (2006). Iron chelation by the powerful antioxidant flavonoid quercetin. Journal of Agricultural and Food Chemistry 54:6343-6351. |
|
|
Li Y, Hansen L, Borst B, Spears W, Moeser J (2016a). "Dietary iron deficiency and over supplementation increase intestinal permeability, ion transport, and inflammation in pigs," Journal of Nutrition 146(8):1499-1505. |
|
|
Li Y, Yao J, Han Ch, Yang J, Chaudhry T, Wang S, Liu H, Yin Y, (2016b). Quercetin, Inflammation and Immunity. Nutritional 8:167 |
|
|
Madhusudhan S, Oberoi R (2011). Renal iron deposition in aplastic ane-mia: magnetic resonance imaging appearance. Indian Journal of Nephrology 21:134-135. |
|
|
Matos R, Capelozzi L, Gomes F, Mascio D, Medeiros H (2001). Lycopene inhibits DNA damage and liver necrosis in rats treated with ferric nitrilo tri acetate. Archives of Biochemistry and Biophysics 396:171-177. |
|
|
Nijveldt J, van Nood E, van Hoorn C, Boelens G, van Norren K, van Leeuwen M (2001)."Flavonoids: a review of probable mechanisms of action and potential applications," American Journal of Clinical Nutrition 74(4):418-425. |
|
|
Ohkawa H, Ohishi W, Anal K (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95:351-358. |
|
|
Nunez T, Urrutia P, Mena N, Aguirre P, Tapia V, Salazar J (2012): "Iron toxicity in neurodegeneration," Biometals 25(4):761-776. |
|
|
Pari L, Asaithambi K, Paramasivam K, Ayyasamy R (2015). Protective effects of hesperidin on oxidative stress, dyslipidaemia and histological changes in iron-induced hepatic and renal toxicity in rats. Toxicology Reports 2:46-55. |
|
|
Porter B (1997). A risk-benefit assessment of iron-chelation therapy. Drug Safety 17:407-21. |
|
|
Qi L, Cao C, Hu L, Chen S, Zhao X, Sun C (2017). Metabonomic analysis of the protective effect of quercetin on the toxicity induced by mixture of organophosphate pesticides in rat urine:Human and Experimental Toxicology 36(5):494-507. |
|
|
Raza A, Xu X, Xia L, Xia C, Tang J, Ouyang Z (2016). Quercetin-Iron Complex: Synthesis, Characterization, Antioxidant, DNA Binding, DNA Cleavage, and Antibacterial Activity Studies: Journal of Fluorescence 26:2023-2031. |
|
|
Singh P, McCoy T, Tice R, Schneider L (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Experimental Cell Research 175(1):184-191. |
|
|
Sinha R, Srivastava S, Joshi A, Joshi J, Govil G (2014). In-vitro anti-proliferative and anti-oxidant activity of galangin, fisetin and quercetin: role of localization and intermolecular interaction in model membrane. European Journal of Medicinal Chemistry 79: 102-109. |
|
|
Stookey LL (1970). "Ferrozine-A New Spectrophotometric Reagent for Iron," Analytical Chemistry 42(7):779-781. |
|
|
Tice R, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae E, Ryu C, Sasaki F (2000). Single cell gel/ cometassay: guidelines for in vitro and in vivo genetic toxicology testing. Environmental and Molecular Mutagenesis 35:206-221. |
|
|
Torreggiani A, Tamba M, Trinchero A, Bonora S (2005). Copper (II)–Quercetin complexes in aqueous solutions: spectroscopic and kinetic properties. Journal of Molecular Structure 744:759-766. |
|
|
Torti V, Torti M (2013). Iron and cancer:more ore to be mined. Nature Reviews Cancer 13: 342-355. |
|
|
Uranga M, Salvador A (2018). Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology. Oxidative Medicine and Cellular Longevity, Article ID 2850341, 12. |
|
|
Urrutia P, Aguirre A, Esparza A, Tapia V (2013). Inflammation alters the expression of DMT1, FPN1 and hepcidin and causes iron accumulation in central nervous system cells. International Society for Neurochemistry. Journal of Neurochemistry 126:541-549. |
|
|
Uzun G, Demir F, Kalender S (2010). Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats. Food and Chemical Toxicology 48:1714-1720. |
|
|
Uzun G, Kalender Y (2013). Chlorpyrifos induced hepatotoxic and hematologic changes in rats: the role of quercetin and catechin. Food and Chemical Toxicology 55:549-556. |
|
|
Valko M, Rhodes J, Moncol J, Izakovic M, Mazur M (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico- Biological Interactions 160:1-40. |
|
|
Valko M, Morris H, Cronin T (2005). Metals, toxicity and oxidative stress. Current Medicinal Chemistry 12:1161-1208. |
|
|
Von Bernhardi R, Eugenin J (2012). Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms. Antioxidants and Redox Signaling 16:974-1031. |
|
|
Yang J, Cao J, Sun X, Feng Z, Hao D, Zhao X, Sun C (2012). Effects of long-term exposure to low levels of organophosphorous pesticides and their mixture on altered antioxidative defense mechanisms and lipid peroxidation in rat liver. Cell Biochemistry and Function 30:122-128. |
|
|
Zantopoulos V, Antoniou V, Pet saga V, Zdrags A (1996). "Copper concentration in sheep liver and kidney in Greece," Veterinary and Human Toxicology 38(3):184-185. |
|
|
Zhang Y, Li H, Zhao Y, Gao Z (2006). "Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury," European Journal of Pharmacology 535(30):263-269. |
|
|
Zhang Y, Gao Z, Liu J, Xu Z (2011). Protective effects of baicalin and quercetin on an iron-overloaded mouse: comparison of liver, kidney and heart tissues. Natural Product Research 25(12):1150-1160. |
|
|
Zivadinov R, Weinstock-Guttman B, Pirko I (2011). Iron deposition and inflammation in multiple sclerosis. Which one comes first? BMC Neuroscience 12:60. |
|
Copyright © 2025 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0
