February 2012
Chemoselective 3-O-alkylation of L-ascorbic acid under phase transfer catalysis
A detailed investigation for synthesis of chemo-selective 3-O-alkylation of L-ascorbic acid under phase transfer catalysis has been carried out. All the compounds were fully characterized by infra red (IR), NMR and microanalysis. Reaction of 5,6-O-isopropylidene-L-ascrobic acid with one equivalent of corresponding alkylating agent and tetrabutyl ammonium iodide as phase transfer catalyst in biphasic system (water:ethyl...
February 2012
In vitro antimycobacterial studies on the leaf extracts and fractions of Pavetta crassipes K. Schum
Tuberculosis is a major public health threat and Nigeria has the world’s fifth largest tuberculosis burden, with nearly 311,000 estimated cases annually. Mycobacterium tuberculosis, the causative organism, has acquired resistance against most of the current chemotherapy, thereby calling for the urgent development of new antituberculosis drugs. Preliminary phytochemical and antimycobacterial studies were...
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