September 2007

Phytochemical antioxidants for health and medicine – A move towards nature

Oxidants or reactive oxygen species are produced in our body during aerobic metabolism leading to many diseases such as cancer, cardiovascular diseases etc. Antioxidants are the chemicals that neutralize these oxidants. Natural antioxidants are the secondary metabolites of phytochemicals and are preferred over synthetic antioxidants, which are found to impose side effects. A review has been done on the effect of...

Author(s): Duduku Krishnaiah, Rosalam Sarbatly and Awang Bono

September 2007

Proof of Evidence: PPAR-induced ANGPTL4 in Lipid and Glucose Metabolism

Angiopoietin-like protein 4 (ANGPTL4) was identified as a peroxisome proliferator-activated receptor (PPAR)-induced gene. The genetic finding that mutation in ANGPTL3 causes hypolipidemia in mice moved us to test whether ANGPTL4 could also regulate lipid metabolism in vivo. We successfully proved that the introduction of ANGPTL4 as well as ANGPTL3 protein into mice rapidly induced hyperlipidemia. This suggests that...

Author(s): Kenichi Yoshida