January 2009

Diagnostic modeling with differences in plasma amino acid profiles between non-cachectic colorectal/breast cancer patients and healthy individuals

Metabolic changes in patients with cancer lead to alterations in their amino-acid balances. Thus, amino-acid profiles may be useful as biomarkers of cancers. This study was conducted to analyze amino-acid profiles in plasma by multivariate analysis, in order to elucidate differences between cancer patients and controls. Venous blood samples were taken from colorectal and breast cancer patients, and healthy controls....

Author(s): Naoyuki Okamoto, Yohei Miyagi, Akihiko Chiba, Makoto Akaike, Manabu Shiozawa, Akira Imaizumi, Hiroshi Yamamoto, Toshihiko Ando, Minoru Yamakado and Osamu Tochikubo

January 2009

Association of angiotensin converting enzyme gene I/D polymorphism with vitiligo in South Indian population

Vitiligo or leukoderma is a chronic skin condition that causes loss of pigment due to destruction of melanocytes, resulting in irregular pale patches of skin. Vitiligo is polygenic disease and associated with autoimmunity. Angiotensin converting enzyme (ACE) is capable of modulating cutaneous neurogenic inflammation. An insertion/deletion (I/D) polymorphism of a 287-base pair repetitive sequence in intron 16 of the ACE...

Author(s): Farha Deeba⊃, Kaiser Jamil⊃, Syed Rabbani⊃, M.A.Waheed⊃ and Hanmanth Rao⊃