January 2011

EGFP-FMRP forms proto-stress granules: A poor surrogate for endogenous FMRP

Overexpressed autofluorescent-tagged versions of the Fragile mental retardation protein (FMRP) such as EGFP-FMRP have been used in protein-protein interaction studies and in studies of the composition, the formation and the localization of neuronal granules. However, the question of whether these molecules...

Author(s): Natalia Dolzhanskaya, Wen Xie, George Merz and Robert B. Denman

January 2011

Virulence prediction model (virprob) using amino acid and dipeptide composition for human pathogens

Pathogenic bacteria that cause infectious disease are operated by various virulence mechanisms. Hence, it is important to develop a reliable system for predicting bacterial virulent proteins aiming at discovering novel drug/vaccine and for understanding virulence mechanisms in pathogens. On the basis of features like amino acid and dipeptide composition, it tried to identify the virulence potential in the given...

Author(s): S. B. Muley, V. Bastikar, S. Bothe, A. Meshram and N. Roy