January 2010

Genome scan meta-analysis in systemic lupus erythematosus strong linkage with loci 6p22.3-p21.1 and 2q31.1-34

The genetic contribution to development of system lupus erythematosus (SLE) is well established. Several genome scan studies have identified putative susceptibility loci to SLE. However; they have shown high level of inconsistency. Genome search meta-analysis (GSMA) which is a non-parametric method is used to identify genetic regions that rank high on average in terms of linkage statistics across...

Author(s): Suad AlFadhli, Najla AlKharrat and Ahmid AlRebai

January 2010

Genotyping CTLA-4 exon 1 (+49 A/G) and HLA-DRB1 polymorphisms and susceptibility to systemic lupus and rheumatoid arthritis in Tunisian population

Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a negative regulator of T-cell function, which has been suggested to be involved in a wide-range susceptibility to autoimmune diseases. We sought a probable implication of the CTLA-4 polymorphism (A/G +49) in two autoimmune diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and its possible interaction with HLA-DRB1 polymorphism....

Author(s): Imen Sfar, Tarak Dhaouadi, Henda Krichen, Asma Elbeldi, Leila Abdelmoula, Mouna Makhlouf, Thouraya Ben Romdhane, Salwa Jendoubi-Ayed, Houda Aouadi, Taieb Ben Abdallah, Khaled Ayed, Rafik Zouari and Yousr Lakhoua-Gorgi