September 2016

Aqueous extract of Bowdichia virgilioides stem bark inhibition of allergic inflammation in mice

This study evaluated the anti-allergenic properties of the aqueous extract of the stem bark from Bowdichia virgilioides (AEBv). Oral administration of AEBv inhibited the plasma protein leakage at 30 min post allergenic challenge in Swiss mice actively sensitized with ovalbumin (OVA). AEBv inhibited OVA-induced histamine release in vitro in tissues obtained from sensitized mice. AEBv-treated mice exhibited a lower influx...

Author(s): Juliane Pereira da Silva, Jamylle Nunes de Souza Ferro, Benisio Ferreira da Silva Filho, Luiz Antônio Ferreira da Silva, Tayhana Priscila Medeiros Souza, Heloisa de Carvalho Matos, Vinicius de Frias Carvalho, Renato Santos Rodarte and Emiliano Barreto

September 2016

Sensitization with babassu mesocarp induces activation of murine splenocytes against tumor cells

Attallea speciosa Mart. (babassu) fruit contains a mesocarp that is rich in carbohydrates with immunomodulatory effects. The induction of the tolerogenic response is a tumor escape mechanism, and immunomodulator adjuvants have been studied to reestablish host immunogenicity. This study evaluates the adjuvant potential of babassu mesocarp carbohydrates in a tumor model. The babassu mesocarp extraction (BME) yield was...

Author(s): Leticia Prince P. Pontes, Josemar M. F. Godinho Jr., Elza Moraes, Diego S. Arruda, Caroline S. C. Almeida, Mayara C. Pinto, Graciomar C. Costa, Rosane N. M. Guerra, Luce M. B. Torres, Vanessa F. Oliveira, Flávia R. F. Nascimento and Ana P. S. Azevedo-Santos

September 2016

Curcuma comosa ameliorates cisplatin-induced nephrotoxicity: COX-2 expression and ultrastructure changes

To determine the protective effects of ethanol extracts of Curcuma comosa on kidney injury by cisplatin, mice were randomly assigned into 4 groups: Control, cisplatin control (12.5 mg/kg body weight (BW), i.p.), C. comosa+cisplatin (pretreatment with C. comosa at dose 200 mg/kg BW orally for 4 consecutive days before cisplatin injection), and C. comosa control groups. After five days, the renal tissues were collected to...

Author(s): Alan Chuncharunee, Valainipa Habuddha and Aporn Chuncharunee