February 2014
Antimicrobial and antioxidant activities of substituted halogenated coumarins
Pathogens frequently display resistance to current drugs, which frequently lack selectivity/efficacy and have detrimental side effects. Thus, there is a constant need for novel therapeutic agents. Coumarins belong to the family of lactones, having a benzopyrone system that can be isolated from plants as well as total synthesis that can be carried out in the laboratory. To date, many chemical reactions have been...
February 2014
A sensitive high performance liquid chromatography-ultraviolet (HPLC-UV) method for the quantitation of α-obscurine in rat plasma and its application to pharmacokinetic studies
A simple and sensitive high performance liquid chromatography (HPLC) method for the determination of α-obscurine in rat plasma has been developed and validated. Separation was achieved on Century Sil EPS C18 (5 μm, 200 × 4.6 mm i.d). The mobile phase, water:methanol:triethanol amine (39:61:0.05 v/v/v), was delivered at a flow rate of 1.0 ml/min. The detector was set at 250 nm. No interfering chromatogram...
February 2014
Polygonatum cirrhifolium Royle and Polygonatum verticillatum (L.) Allioni: Status assessment and medicinal uses in Uttarakhand, India
Polygnatum verticillatum (Linn) All. and Polygonatum cirrhifolium (Wall.) Royle (Liliaceae) growing in the Himalayan region is assigned as vulnerable by International Union for Conservation of Nature and Natural Resources (IUCN). To elucidate the status of the plants in the Uttarakhand Himalaya population assessment of the species is done in the study region. The study area is divided into five sites (Kilburry,...
February 2014
Water extracts of dietary mushrooms, Agrocybe aegerita and Hypsizigus mamoreus, inhibit antigen expression of human hepatitis B virus
Hepatitis B virus (HBV) infection is prevalent but the current treatments remain to be improved. This study evaluated the effect of dietary mushrooms on expression of surface (HBsAg) and e (HBeAg) antigens of HBV. Hot-water extracts (HWE) of dietary mushrooms, Agrocybe aegerita (AA), Hypsizigus mamoreus (HM) and Flammulina velutipes (FV), were prepared and subjected to gel permeation chromatograph for molecular weight...
February 2014
Study on callus induction and plant regeneration of Leuzea carthamoides via tissue culture system
Leuzea (Rhaponticum carthamoides) is a valuable medicinal plant from Asteraceae. Micropropagation could be a good alternative for the mass propagation of Leuzea carthamoides. To investigate the callogenesis of leaf explants, 12 different hormonal combinations including different concentrations of 16-benzylaminopurine (BA) and 2,4-dichlorophenoxyacetic acid (2, 4-D) were studied in two separable experiments. In both...
February 2014
Effects of extracts from Linum usitatissimum on cell vitality, proliferation and cytotoxicity in human breast cancer cell lines
The seeds of flax (binomial name: Linum usitatissimum L.) are well known for their high content of phytoestrogens. In the present study, extracts from roots, leaves and stems of flax were analysed for their content of compounds, which might have phytoestrogen-like properties, by pyrolysis field ionisation mass spectrometry. All extracts were tested on the human breast cancer cell lines MCF7 (estrogen receptor positive)...
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