Oxidative injury and enzymic antioxidant misbalance in schizophrenics with positive, negative and cognitive symptoms
With its hallucinations, delusions, thought disorder, and cognitive deficits, schizophrenia affects the most basic human processes of perception, emotion, and judgment. Evidence increasingly suggests that schizophrenia is a subtle disorder of brain development and plasticity and oxidative injury contributes largely to pathophysiology of schizophrenia, indicated by the increased lipid peroxidation products in...
Characterization of phospholipase A2 (PLA2) from Echis ocellatus venom
Phospholipase A2 (EC. 184.108.40.206) was isolated and partially characterized from the venom of Echis ocellatus. The enzyme was purified 13.5-fold with a yield of 86.69% on DEAE-Sephadex G-75 column. The PLA2 from E. ocellatus venom had broad pH and temperature ranges with optima of 7.5 and 40oC respectively. Initial velocity studies for the determination of kinetic constants with...
Decreased cardiovascular risk and resistance to hyperlipemia-induced hepatic damage in rats by aqueous extract of Urtica dioica
Hyperlipemia and Hepatic metabolism was studied in hyperlipemic albino rats maintained on a high fat diet. Aqueous extract (100, 200, 300mg/kg/day) of Urtica dioica corrected dyslipidemia and restored hepatic chemistry in hyperlipemic animals. The extract was effective in normalizing the atherogenic lipoprotein phenotype. Total cholesterol (CHOL), Triglyceride (TG), Low density lipoprotein...