African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007

AJBR Articles in press

Properties of antioxidants produced by Rhodobacter sphaeroides

Article in Press

In this study, we investigated the properties of antioxidants produced by Rhodobacter (R.) sphaeroides, a purple, non-sulfur photosynthetic bacterium. R. sphaeroides was fractionated into water-soluble and ethanol-soluble fractions, and the ethanol-soluble fraction showed stronger activity. Light irradiation significantly decreased the antioxidant activity of the ethanol fraction. The absorption spectra of the ethanol...

Author(s):Tomoaki Deguchi, Tomomi Ezaki, Miki Sato, Masayuki Kobayashi

The evaluation of oxidative stress and antioxidant status in Brucella patients treated with two type of antibiotic combination

Article in Press

Brucellosis is a zoonotic infectious disease and a significant public health problem in the World. Oxidative stress is an imbalance oxidant/antioxidant status of the body, and plays an essential role in the pathogenesis of many infectious diseases such as brucellosis. The present study aimed to evaluate the oxidant/antioxidant status in pre- and post-treated brucella patients, and to determine whether the effects of...

Author(s):Emrah Caylak

Antioxidation and Cytoprotection Mechanisms of Ficus asperifolia in Diabetic Rats

Article in Press

Background: The current study tested the hypothesis that Ficus asperifolia from West Africa could be used as an anti-diabetic plant through the antioxidation and cytoprotection mechanism using a diabetic murine model. Methods: An unbiased metabolomics approach applied include: vitamins, mineral contents, ferric reducing-antioxidant power (FRAP), and thiobarbituric acid reactive substance (TBARS) were analyzed...

Author(s):Faith Pwaniyibo Samson, Ambrose Teru Patrick, Margret Samuel Nadro and Wan Jin Jahng

ASSOCIATION BETWEEN BODY MASS INDEX AND SOME BIOCHEMICAL INDICES IN SELECTED OBESE AND NORMO-WEIGHT INDIVIDUALS FROM SOUTH-WEST NIGERIA

Article in Press

Obesity is fast becoming an endemic disease associated with various other complications due to nutritional imbalance. The study was set up to assess the plasma levels of glucose, cholesterol and selected electrolytes in obese and normo-weight individuals. The weights and heights of healthy individuals were measured and the body mass indices (BMI) calculated in kg/m2. Individuals with BMI> 30 were considered obese while...

Author(s):Temitope Abiola, Ibukun T. Sossou, Olakunle A. Akinyode, Olumuyiwa Omoloja

Effect of Dietary Administration of Bixa orellana Seeds on Liver and Kidney Parameters in Rats

Article in Press

Bixa orellana seed powder is used as a natural food colorant in many locally prepared foods of northern Nigeria. This study was conducted to determine the effect of dietary exposure to B. orellana whole seeds on liver and kidney parameters in male rats. Twelve male Wistar rats (4 rats/group) were fed diet mixed with B. orellana seed powder at 0, 0.5 and 5% for four weeks. Animal body weight, food consumption, absolute...

Author(s):Wilson Obidah, Abdullahi Sule, Michael A. Madusolumuo, Daniel Dahiru, Lucas C. Domkat

Study of isoforms of nicotinamide adenine dinucleotide phosphate oxidase of the heart in a model of rats fed on several vegetable oils.

Article in Press

Palm oil has long been incriminated in obesity, and this obesity would be responsible for the development of cardiac fibrosis, several authors have evoked the role of free radicals in the pathophysiological mechanism of the fibrotic response linked to obesity; The aim of this study was therefore to evaluate the profile of NOX2 in the development of cardiac fibrosis in rats subjected to a diet rich in the fat of several...

Author(s):KOFFI KONAN GERVAIS

Dynamics of Ascaridigalli infection and serum retinol level following supplementation with Vitamin A

Article in Press

The present study was conducted to assess the effect of Ascaridia galli infection on vitamin A supplementation and serum retinol concentrations. These were assessed in 100 eight weeks ISA brown chickens experimentally infected with A. galli. The chickens were divided into four equal groups (G1, G2, G3 and G4) of ten chickens (n=10). The chickens were experimentally infected with 350 eggs of A. galli and daily supplemented...

Author(s):George Gaymary Bakari, Elifuraha Barnabas Mngumi, Robert Arsen Max and Amandus Muhairwa

Some physicochemical Properties of a 49.7 kDa Glutathione Transferase from African Palm Weevil (Rhynchophorus Phoenicis) Larvae

Article in Press

Glutathione transferase is a mutigene family of enzymes catalyzing the conjugation of glutathione with a large variety of xenobiotics. Glutathione transferase acts on different substrates and can protect insects against various plant allelochemicals and chemical insecticides. An investigation of glutathione transferase in the gut of Palm weevil (Rhynchophorus phoenicis) larva, a lethal pest of palm was carried out. This...

Author(s):Bamidele O. Samuel, Ajele J. Oluwafemi

Ascorbic acid attenuates hematological and hepatic derangements in rats co-treated with Atrazine and sodium nitrate

Article in Press

The present study examined the roles of ascorbic acid (AA) on hematological indices, hepatic function and lipid profile, and liver histology in rats co-treated with Atrazine (ATZ) and sodium nitrate (NaNO3). The hematological indices, liver function tests, lipid profile, and liver histology were performed using standard protocols. The [ATZ + NaNO3] significantly (p < 0.05) reduced the levels of hemoglobin, red blood cells,...

Author(s):Adeleke Gbadebo Emmanuel, O.K. Raheem, Adedosu, Olaniyi Temitope, Fatoki John Olabode

Tamoxifen treatment improves serum lipid profile with possible cardio-protective effect.

Article in Press

Breast cancer is the most widely recognized cancer in women worldwide and it is the main source of cancer demise in less created nations. Dyslipidemia in breast cancer patients has been considered as a hazard factor for cardiovascular diseases. Tamoxifen is basically hostile to estrogenic and its estrogenic action is fundamentally liable for the adjustments in lipid parameters. Investigation of lipid profiles among breast...

Author(s):Solomon Genet,Bihonegn Berhan, Wondemagegnehu Tigeneh, Tigistu Gebretensaye

IN VITRO ANTIOXIDANT ACTIVITIES OF Carissa edulis VAHL AND Caesalpinia volkensii HARMS EXTRACTS

Article in Press

Carissa edulis and Caesalpinia volkensii have been used through ages by herbalists in many parts of the world to treat various ailments. Although these medicinal plants have been widely used traditionally in treating diseases associated with oxidative stress, there is limited literature to validate their use. This study therefore, sought to determine the ethnobotanical efficacy of the plants as alternatives in the...

Author(s):Kibiwott Jepkorir Scolar, Ng’ang’a Mwihaki Margaret, and Ngugi Mathew Piero

A comparative study on determination of selected essential and heavy metals from Avocado, Mango and Banana with their supporting soil samples cultivated in Yeki Woreda, Southwest Ethiopia

Article in Press

The study was focused on the quantitative determination of some selected essential and heavy metals in avocado, banana and mango samples with their respective supported soil samples collected from 8 kebeles of Yeki woreda. The investigated metals were Ca, Cd, Cr, Cu, Ni, Pb and Zn. Acid digestion was used for sample digestion. Flame atomic absorption spectrometer (FAAS) was used to determine the concentration of metals....

Author(s):Berhe Akele, Shisho Haile

EVALUATION OF ANTIMALARIAL ACTIVITY, ACUTE ORAL TOXICITY AND IN SILICO ADMET PROFILES OF 3-CHLORO-4-(4-CHLOROPHENOXY) ANILINE AND ITS ARTESUNATE HYBRID

Article in Press

The global malaria control and elimination strategies are constrained by the emergence and spread of multi-drug resistant Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae strains to most antimalarials. Currently, studies reveal rising incidences of reduced parasite susceptibility to the artemisinin-based combination therapies (ACTs), the recommended first-line treatment regimen for uncomplicated P....

Author(s):Milka Wambui, Daniel Wainaina Kariuki, Johnson Kang’ethe Kinyua, Francis Thuo Kimani and Joseph Kang’ethe Ng’ang’a

Acute oral toxicity study of Acacia nilotica bark of aqueous methanolic extract in albino mice

Article in Press

The beneficial use of medicinal plant among rural communities has been reported over century’s medicinal properties and toxicity of the plant varies depending on the part of the plant taken like leaves, roots, stem and bark as well as geographical distribution, climate change and nature of the soil. This study aimed to assess the acute toxicity of Tanzania Acacia nilotica extracts in mice. The information generated is...

Author(s):Raphael Mwezi, Revocutus L Machunda, Hamisi M Malebo

In vivo antimalarial activity of bark extracts of Lannea acida (anacardiaceae) and chloroquine against Plasmodium berghei in mice.

Article in Press

Lannea acida plants belong to the family Anacardiaceae. It has been used locally to treat and manage diseases that are contagious. Due to the recent increase in the resistance of malaria parasite to synthetic drugs the search for alternative treatment approach from plant sources is in urgent dimension. The antiplasmodial activity of mice was investigated with L. acida bark extracts. The study of the acute toxicity of the...

Author(s):Olusola A. O, Ogunsina O.I., Ayedogbon S.O, Olusola, A.O

Cardioprotective effect of methanolic extract of Magnifera indica (mango) seed flour on acetaminophen-induced cardiotoxicity in albino rats

Article in Press

This study evaluated the effect of methanol extract of mango (Magnifera indica) seed flour on acetaminophen-induced cardiotoxicity in albino rats. Twenty four (24) male and female albino rats were divided into 6 groups consisted of 4 rats: a)Group1: Control group (no induction and treated with distilled water only);b) Group 2 (acetaminophen-induced and untreated); c) Group 3 (acetaminophen-induced and pre-treated with...

Author(s):Nkwocha, Chinelo Chinenye

Improvement and validation of 96 well-microtiter plate-ABTS based assay for estimation of antioxidant activity in green leafy vegetables

Article in Press

The objective of our study was to develop 96 well-microtiter plate 2, 2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) based decolorization assay method for analysis of large number of samples in a single run for the screening of antioxidant activity of various extracts such as food extracts, plasma antioxidants and synthetic antioxidants and optimization was carried out for parameters like concentration,...

Author(s):Meera I, Sivakumar ChV, Tekeba Sisay

BLOOD STABILITY PARAMETERS AS INDICES OF HEMATOLOGICAL DISORDERS REMAIN PRESERVED ON EXPOSURE TO CORCHORUS OLITORUS LEAF CONSUMPTION

Article in Press

This study focused on the integrity retention profile of hematological disorder indices on exposure to ethanol extract of Corchorus olitorus leaf. Seventy two apparently healthy rats were obtained from the animal farm of the Department of Zoology and Environmental Biology University of Nigeria, Nsukka and used for this study. These indices include assessed were Red blood cell distribution width standard deviation, Red...

Author(s):OMEJE KINGSLEY OZIOMA

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