June 2009

Comparative methaemoglobin concentrations of three erythrocyte genotypes (HbAA, HbAS and HbSS) of male participants administered with five antimalarial drugs

  In the present in-vivo study, the capacities of five antimalarial drugs (Fansidar, Halfan, Quinine, Coartem and Chloroquine phosphate) to alter/distort methaemoglobin concentrations of three human erythrocyte genotypes (HbAA, HbAS and HbSS) was investigated. Spectrophotometric method was used to ascertain this erythrocyte parameter. The male participants enrolled for this study were grouped...

Author(s): P.C. Chikezie

June 2009

Purification of a mannose/glucose-specific lectin with antifungal activity from pepper seeds (Capsicum annuum)

  A lectin was isolated and purified from the pepper seeds Capsicum annuum. The purification procedure involved anionic exchange chromatography on DEAE – Cellulose and QAE – Sephadex columns followed by gel filtration on Sephadex G–100. The heamagglutinating activity of the lectin towards human erythrocytes was sensitive to inhibition by D-mannose and D-glucose; and enhancement by...

Author(s): Adenike Kuku, Oludele Odekanyin, Kemi Adeniran, Mary Adewusi and Toyin Olonade