Lavudine therapy and hepatotoxicity as seen in a Nigerian tertiary antiretroviral treatment centre
Hepatic toxicity is a common complication of anti-retroviral treatment in HIV patients, usually indicated or heralded by the elevation of liver transaminases measured in the blood. There had been reported evidence of hepatic toxicity in all the three currently approved classes of anti-retroviral drugs. However, its severity in some cases...
Quantitation of alcohols in orange wine fermented by four strains of yeast
Gas liquid chromatography was used to identify the types of alcohol present in wines produced by fermenting orange juice with four strains of yeast; Saccharomyces cerevisiae (isolated from yam), S. cerevisiae (from sugarcane molasses),Saccharomyces carlsbergensis (from sugarcane molasses) and S. cerevisiae var. ellipsoideus (from orange juice). Ethanol and methanol were the...
Effect of Emblica officinalis against alcohol-induced biochemical changes in plasma and red blood cells of rats
Alcohol is widely abused as a psychoactive drug. Emblica officinalis is known for its therapeutic effects and the present study is aimed at investigating therapeutic efficacy of aqueous extract of Emblica officinalis (AEEO) against alcohol-induced damage. Thirty three percent (v/v) alcohol (10 g/kg body weight) and AEEO (250 mg/kg body weight/day) was orally administered once a day for 60...
Biochemical characterization of two Î± -mannosidases from breadfruit (Artocarpus communis) seeds
The importance of α -mannosidases in glycoproteins processing and their application in food and pharmaceutical industry led us to further explore plant α -mannosidases. Thus, two α -mannosidases were purified from matured breadfruit (Artocarpus communis) seeds, by successive chromatography on Diethylaminoethyl-Sepharose CL-6B and Sephacryl S-200 HR to apparent...
Protective effect of betaine on changes in the levels of protein, glycoproteins and amino acids in isoprenaline-induced myocardial infarction in rats
The protective effect of betaine administration on changes in the levels of protein, glycoproteins and amino acids was studied in isoprenaline-induced myocardial infarction in rats as an animal model of myocardial infarction in man. Oral pre-treatment with betaine significantly (P<0.05) attenuated the isoprenaline-induced rise in the levels of troponin-T...
Garcinia kola extract reduced cisplatin-induced kidney dysfunction in rats
The effect of Garcinia kola extract on cisplatin-induced renal insufficiency in rats was studied. A total of fifteen rats were used for the study and were split into three groups of five rats per group. Rats in group I were normal controls. Renal insufficiency was induced in rats of groups II and III by a single intraperitoneal administration of cisplatin (5 mg/kg b.w.). After three days, rats in...