African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Table of Content: October-December 2020; 14(4)

October 2020

Antimalarial pyronaridine resistance may be associated with elevated MDR-1 gene expression profiles but not point mutation in Plasmodium berghei ANKA isolates

The selection of resistance is inevitable whenever chemotherapy is necessary for pathogen control. Notably, Plasmodium falciparum has developed multifaceted means to overcome the toxicity of nearly all antimalarial medicines. To bypass this challenge, not only should novel drugs be developed, but the resistance mechanisms to new and existing drugs need should be fully explored. Pyronaridine is a companion drug in...

Author(s): Shadrack Kanyonji Kimani, and Jacob Manyiwa Shume,  

October 2020

Sub-acute and protective effect of Cymbopogon citratus against carbon tetrachloride-induced liver damage

The study evaluates the sub-acute toxicity and antioxidant potential of ethanolic leaf extract of Cymbopogon citratus against CCl4-induced toxicity in Sprague Dawley rats. The ethanolic leaf extract of C. citratus was prepared by solvent maceration method. The phytochemicals present in the extract were determined using standard methods. The potential sub-acute toxicities were evaluated using OECD procedure. The...

Author(s): Momoh Johnson Oshiobugie, Aderele Oluwaseun Raphael and Rasaq Adekunle Kareem

October 2020

Insulin resistance and specific biomarkers in blood and urine of type 2 diabetic patients with or without nephropathy in Basrah, Iraq

Diabetic nephropathy (DN) is a master cause of all surplus death-rate among type 2 diabetes mellitus (T2DM) patients with microalbuminuria. This study aimed to find effective biomarkers for early predicting of DN. Present study included 63 patients with T2DM (31 patients with DN, 32 patients without DN) and 33 healthy controls. These three groups were matched for their glucose, urea, creatinine, insulin, L-Carnitine...

Author(s): Adnan Jassim Mohammed Al-Fartosy, Nadhum Abdulnabi Awad and Sadoun Abbas Alsalimi,  

October 2020

Correlation between glycated hemoglobin and venous blood sugar in diabetic patients monitored in Abidjan

The aim of this study was to determine the correlation between glycated hemoglobin and blood sugar levels in diabetic subjects carried out in Abidjan. This cross-sectional study included 100 patients with diabetes monitored, for three months, for whom glycated blood glucose and hemoglobin were performed, this after informed consent of the patients. Pearson and Spearman correlation tests were used, at the 5% threshold....

Author(s): MONDE Aké Absalome, CAMARA-CISSE Massara, KOFFI Konan Gervais, DIALLO Issiagha, AKE AKE Alexandre, YAPO-AKE Bénédicte, ECRABEY Yann Christian, KOUAKOU Francisk, BENE YAO Roger Espérance and TIAHOU Georges

October 2020

Evaluation of acute oral toxicity, hemato-biochemical activity and physiological responses of rabbits and rats administered Moringa oleifera leaf extract and meal

The present study aims to evaluate acute oral toxicity of leaf extract of Moringa oleifera and determine the effect of the leaf’s meals of this plant on hematological and biochemical parameters of the rabbit. Ten rats weighing 150 ± 200 g were used for the oral acute toxicity study. Five rats received orally a single dose of 2000 mg/kg of weight of aqueous extract and 5 rats used as control....

Author(s): Basile Boni Saka Konmy, Pascal Abiodoun Olounladé, and Sanni-yo Doko-Allou,