September 2008

Protein profiles of adrenal gland of neonatal rat treated with monosodium glutamate

  Exposure to excessive monosodium glutamate (MSG) during neonatal life has been correlated with loss of function in stress response that might be involved in changes of adrenal activity. This study was designed to investigate the protein pattern and examine the mRNA level of proteins in the adrenal glands following MSG stimulation. Neonatal rats were subcutaneously administered with MSG at a concentration of 4...

Author(s): Anuwat Wanthong, Sompong Thammasirirak and Khomsorn Lomthaisong

September 2008

Nicotinamide: A cytoprotectant against streptozotocin-induced diabetic damage in Wister rat brains

  Nicotinamide is being used in experimental and clinical trials examining the prevention of type-1 diabetes mellitus. However, the precise mechanisms underlying the antidiabetic and neuroprotective effects of nicotinamide require further analysis. Our goals are to evaluate the protective effect and the cellular and molecular mechanisms of nicotinamide against brain damage induced by type-1 diabetes in...

Author(s): Safinaz S. Ibrahim and Sherine M. Rizk