Aim: To determine the hemorhelogical alterations in normal pregnant women in Benin City, Nigeria. Methods: Subjects aged between 18 and 42 years participated in the study. Patient consent form was obtained from 240 pregnant women on antenatal visit and 80 aged matched healthy individual on routine checkup. The

pregnant women were divided into three groups according to trimesters. Those with complications were excluded from the study. Creactive proteins and fibrinogen concentrations were estimated using enzyme linked immunosorbent assay method. Erythrocyte sedimentation rate was estimated using the Westergren method. Relative plasma viscosity was estimated using the simple syringe and needle apparatus. Results: There was a significant increase (P< 0.05) in FC, RPV, CRP and ESR at stage 1 when compared with stages 2, 3 and 4. Conclusion: The elevation of fibrinogen concentration, relative plasma viscosity, C reactive protein and erythrocyte sedimentation rate are associated with normal physiological adaptive mechanism of the blastocyst to get itself engraft onto the wall of the endomentrium from where it can obtain nourishment.

 

Keywords: Adaptive immunity, Fibrinogen, Endomentrium, Acute phase proteins.