December 2015

Effect of canagliflozin or metformin on metabolic disorders in obese diabetic rats

This study aimed to investigate the effect of canagliflozin (CAN) or metformin (MET) on investigated biochemical parameters in obese diabetic rat model. Obesity induced by melted butter administration and hyperlipidemic rats were subjected to streptozotocin (STZ; 35 mg/kg i.p) to develop the diabetic model (D). Animals were grouped as control (C), D none treated and diabetic treated with CAN (10 mg/kg) or MET (100...

Author(s): Mohamed-Assem S. Marie, Nadia Mohamed Said Arafa, and Sara Abdullah Mubarak Alazimi