African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007

AJPP Articles in press

In vivo studies of the immunomodulatory effect of aqueous extract of Artemisia herba alba

Article in Press

Historically Artemisia herba alba (AHA) is widely used in traditional Moroccan medicine. Few studies have been carried out to confirm its traditional use, in particularly immunological studies and to our knowledge, no study has treated the in vivo immunomodulatory effect of AHA aqueous extracts. This work was established to assess the immunological effects of AHA, including the humoral and cellular immunity effects in...

Author(s):Ali Lahna, Abdeljaouad Ezzahir, Martin Ndayambadje, Youness Limami, Younes Zaid, Abdallah Naya and Mounia Oudghiri

Assessment of the immunomodulatory activity of the aqueous extract of ARTAVOL® in Plasmodium berghei Infected Mice.

Article in Press

ARTAVOL® is a herbal product derived from de-artemisinised extracts of Artemisia annua combined with lemon grass extract and avocado seed powder as a base. It is locally used in Uganda for malaria prevention. This study assessed the immunomodulatory activity of the aqueous extract of ARTAVOL® in Plasmodium berghei infected mice. The study employed a controlled in-vivo experimental design in which the effects the aqueous...

Author(s):Martin Amanya, Clement O. Ajayi, Bernard Natukunda, Francis Wasswa, Alice Bayiyana , Rose Nabatanzi, Obondo J. Sande and Amon G. Agaba

Evaluation of the pharmaceutical quality of two nutraceutical lysine products in South Africa

Article in Press

Dietary supplements, particularly nutraceuticals, are an expanding sector on the South African market, especially since the beginning of the COVID-19 pandemic. However, regulatory authorities do not regulate nutraceuticals and a concern arises regarding safety, quality and efficacy of the product reaching the end-user. The aim of the study was to evaluate the pharmaceutical quality, specifically the physical and the...

Author(s):Jonathan Tinotenda Chanyandura and Norman Zivai Nyazema

Investigation of the optimal immunosuppressive dose of cyclophosphamide in wistar rats (Rattus norvegicus) raised in a pharmacology laboratory in Abidjan, Ivory Coast

Article in Press

A recent experimental study was conducted in a pharmacology laboratory in Abidjan on the immunomodulatory activity of a plant remedy. The dose of cyclophosphamide used to depress the rats in the study at the beginning of the experiment did not give the expected results. The objective of this work was to determine the optimal dose of immunosuppressive cyclophosphamide in wistar rats raised in this laboratory. This was an...

Author(s):Eric Gbongué TIA, Thierry-Lenoir Ayoman DJADJI, Landry Sylvain KOUAKOU and Gisèle N’doua KOUAKOU-SIRANSY

Prevalence of gastric diseases linked to Helicobacter pylori, retrospective study in West region (Dschang city) in Cameroon, from 2008 to 2018 and therapeutic trial based on extracts of Nauclea pobeguinii (Rubiaceae)

Article in Press

The prevalence of various gastric diseases is poorly documented around the world, particularly in Africa and more specifically in Cameroon. Their treatment till today remains an important subject of study. Nauclea pobeguinii is a plant in the Rubiaceae family and is commonly used in traditional medicine to treat illnesses such as fever, gastric ulcer, arthritis, and pain. The present research established the...

Author(s):Madjo Kouam Yacine Karelle, Fagni Zenab Njoya Linda, Matah Marthe Vanessa Mba, Ngoufack Azanze Elvira, Tsafack Eric Gonzal, Djuichou Nguemnang Stephanie Flore, Adjouzem Carine Flore and Ateufack Gilbert

In vivo antiplasmodial activity of an aqueous extract of leafy stems of Ipomoea pes-caprea (L.) R.Br. in swiss mice infected with Plasmodium berghei

Article in Press

OBJECTIVE: The study aimed to evaluate in vivo antiplasmodial activity of an aqueous extract of aerial parts of Ipomoea pes-caprea in mice infected with Plasmodium berghei. Extracts of Ipomoea pes-caprea were obtained from the decoction of the dried leafy stem of the plant. The extracts obtained were used for the evaluation of the antiplasmodial activity which was done according to two methods: the rane test was used to...

Author(s):Eric Gbongué TIA, Thierry-Lenoir Ayoman DJADJI, Landry Sylvain KOUAKOU, karim TUO, Etienne Kouakou EFFO, Adebo Yacouba ADEHOUNI, Nounaféri Awa Gniènèfèrètien SILUE, Axelle Edith Ahou KOUADIO, Geneviève N’GUESSAN-IRIE and Gisèle N’doua KOUAKOU-SIRANSY

Antibacterial activities of bidens pilosa l, hoslundia opposita vahl, and ageratum conyzoides l against some common wound pathogens.

Article in Press

Bacterial infection is the main cause of delayed wound healing, and the rising cases of antibiotic resistance call for alternative solutions. Therefore, the search for new therapeutics continues. Hoslundia opposita Vahl, Bidens pilosa L, and Ageratum conyzoides L are among the commonly used plants for wound healing in traditional medicine. This study aimed to determine and compare the antibacterial activity of these plants...

Author(s):Catherine Namuga, Haruna Muwonge, Margaret Lubwama, Nakyejwe Janet, Tahalu Sekulima, John Baptist Kirabira

Formulation and evaluation of gastro-retentive floating tablets of griseofulvin

Article in Press

About 50% of an oral dose of griseofulvin passes through the gastro-intestinal tract unabsorbed and is excreted in faeces. Short residence time of the low soluble griseofulvin, in stomach and small intestine, limits its dissolution. Griseofulvin is highly soluble in acidic pH, and so a gastro-retentive floating matrix system was developed to control dissolution rate and thereby enhance solubility to develop an improved...

Author(s):Jonathan Tinotenda Chanyandura, Madan Sai Poka, Patrick Hulisani Deman, Musa Autamashih

Knowledge, perception and beliefs of human health workers and veterinarians on antimicrobial resistance in Ouagadougou, Burkina Faso

Article in Press

Antimicrobial resistance is a major public health problem in both hospital and community acquired infections. This study assessed knowledge, attitudes and perceptions on antimicrobial resistance among human health workers and veterinarians in Ouagadougou. A cross-sectional study using a self-administered questionnaire was applied among medical health and veterinary structures in Ouagadougou, Burkina Faso on February 2020...

Author(s):Souleymane Soré, Fatimata Bintou Josiane Diarra, Emmanuel Sampo, Sandaogo Hamidou Ouandaogo, Abdoul Salam Ouédraogo, Idrissa Sanou

Determinants and management of cardiac toxicities induced by anthracycline-based regimens in adult patients with cancer at Kenyatta national hospital

Article in Press

Anthracyclines are used in the standard treatment protocols for solid and hematological cancers. Despite their extensive usage, they cause cardiac toxicities. These toxicities require prompt management to reduce the risk of their complications. To investigate the determinants and management strategies of anthracyclines induced cardiotoxicities in adult patients with cancer at Kenyatta National Hospital (KNH). A...

Author(s):Stephen Makori Gichana, Peter N. Karimi, Irene W. Weru and Stanley N Ndwigah

Seroprevalence of IgM and IgG antibodies of contaminated staff in EHUO Hospital detected by RT-PCR during the COVID-19 pandemic

Article in Press

Anti-SARS-CoV-2 serological tests present a major role in the estimation of the prevalence of Covid-19. The objective was to estimate the prevalence of Covid-19 among staff of University Hospital (EHUO) of Oran (Algeria). The study took place between December 2020 and January 2021 in the pharmacovigilance department, in collaboration with the occupational medicine department of the EHU of Oran, a Serological analysis by...

Author(s):A. TACHEMA, F. HAOUATTI, A. SMAIL, H. CHADOU, F. BOUDIA, M. SEDDIKI, A. MEMOU, NFZ. MEKAOUCHE, H. FETATI, R. MEDJANE, H. TOUMI

Characterization of native, acetylated and enzymatically modified amura starch (Taccainvolucrata) for tablets binding

Article in Press

This research is aimed at producing alternative starch used for tablet binding from amura tuber. The Microbiological properties of native and modified amura were determined for bacteria and Fungi load using plate counting method. The physicochemical properties of the native and modified amura starches were determining using standard method, amylose and amylopectin content of native and modified amura starches were...

Author(s):Abubakar M, Dickson M and Evans Egwim

Medicinal Plants of Solanum Species: Promising sources of phyto-insecticidal compounds

Article in Press

Many insects including mosquitoes are important vectors of deadly pathogens and parasites, which in the world’s growing human and animal populations can cause serious epidemics and pandemics. Plants provide a large library of phytochemicals, which can be used to replace chemically synthesized insecticides, and utilization of herbal product-based insecticides is one of the best and safest alternatives for mosquito control....

Author(s):Kumarappan Chidambaram, Krishnaraju Venkatesan; Taha Alqahtani; Kumar Venkatesan, Afaf Aldahish, Kavitha Dhandapani

Bioactive constituents, hepatoprotective and antioxidant activity of the Sub-fractions of Fadogia cienkowskii leaves Schweinf (Rubiaceae)

Article in Press

Background: Fadogia cienkowskiiis claimed to ethnomedicinally cure general body debility, inflammation, liver diseases, oxidative stress-related diseases, diarrhoea, fever, and other ailments. Aim and Objectives: The purpose of this study is to investigate the hepatoprotective and antioxidant activities of the sub-fractions of Fadogia cienkowskii leaves. The bioactive constituents present in the ethanol extract of...

Author(s):Stella O. Bruce, Felix A. Onyegbule, Ogechi O. Anyanwu, Chioma R. Ezenwelu, Christopher O. Ezugwu

Jianpi Mixture Decreases Inflammatory Response in Diarrhea-Predominant-Irritable Bowel Syndrome through the Inhibition of Protease Activated Receptor 2 Signal

Article in Press

To explore the protective mechanism of Jianpi Mixture on diarrhea-predominant-irritable bowel syndrome mice. Methods. To observe the intestinal protection of Jianpi Mixture on intestinal tract of diarrhea-irritable bowel syndrome mouse model. The method for the content determination of serum immunoglobulin A (IgA), IgG, IgM, interleukins and tumor necrosis factor alpha (TNF?) was ELISA. The mRNA levels of IL-1?, IL-6 and...

Author(s):Guoqiang Liang, Xin Yang, Haifeng Yun, Huiping Zhu, Chuan Zhang, and Hongwen Sun

Knowledge, Attitude and Practice of Community Pharmacy Professionals’ towards Substandard and Falsified Medicines in Addis Ababa, Ethiopia: A Cross-sectional Survey

Article in Press

The availability of substandard and falsified medicines in the market grants a serious public health problem and a significant impact on the national economy. Current estimate suggests 10% of prescription drugs sold worldwide are substandard, fake or contaminated, and in parts of Africa and Asia, the figures exceed 50%. Professionals' awareness towards falsified medicines is a major problem that could lead to...

Author(s):Bezawit Girma, Solomon Getnet Meshesha and Zelalem Tilahun Mekonen

Screening of selected nigerian medicinal plants/seeds for growth inhibitory activity against human leukemia hl-60 cells and dpph radical scavenging activity

Article in Press

Leukemia is the most common cancer in children, accounting for a prominent percentage of cancer-related death in that age-group. It is therefore very important to prevent and treat this cancer. In this study, the anticancer effects of 6 different parts of 4 selected species of medicinal plants in Nigerian, especially those grown in South-Western and South-Eastern regions, were investigated on Human leukemic-HL-60 cell line...

Author(s):Saheed Afolabi, Olalekan Agede, Anoka Njan, Olufunke Olorundare, Mamoru Koketsu

Characterization of Nanoparticle-encapsulation of β-carotene Isolated from Daucus carota

Article in Press

β-carotene is a potent lipophilic nutraceutical which has low bioaccessibility and bioavailability caused by poor water solubility, stability, sensitivity to light, temperature and pH. Nano-encapsulation can protect it from degradation and retain a compound's functional property. The aim of this study is to characterize the β-carotene from Daucus carota root which is nano-encapsulated with the chitosan matrix with TPP....

Author(s):Muhamad Taswin, Azza Hanif Harisna, Dwi Wahyu Nugroho, Putri Hawa Syaifie, Etik Mardliyati, Sonlimar Mangunsong and Satheesh Babu Natarajan

Pharmaceutical Studies on the Availability of Aceclofenac from Different Suppository Bases

Article in Press

Aceclofenac is practically insoluble in water, potent non-steroidal analgesic anti-inflammatory drug, with mean maximum plasma concentration of 6.8 mg/L and mean elimination half-life values between 3.5 and 6.2 hours. It was successfully formulated in solid and liquid suppositories using non-ionic surfactants as Spans, Tweens, Witepsols, Suppocires and Brij and also muco-adhesive polymers as Methyl cellulose, Hydroxypropyl...

Author(s):Mahnour A. Fathy, Alaa A. Kassem, Amal Ammar and Shereen A. Eladawy

Post-Market Surveillance of Three Brands of Ibuprofen 400 mg Tablets in Gaborone, Botswana

Article in Press

The supply of sub-standard pharmaceutical products is on the rise. This imposes a greater challenge to health, and hence the need to constantly investigate the quality of medicines to check compliance with international official standards; surveillance. The purpose of the study was to compare three distinct brands of commercially available Ibuprofen 400 mg tablets in Gaborone, Botswana to elucidate compliance through...

Author(s):Livesey David Olerile, Unopa Thabo Ishmael, Amuchilani Waniwa, Thato Tabengwa, Patience Tekanyo

Variation of Antioxidant and Antibacterial Activities of Ethanolic Extracts of Propolis in Three Bee-Keeping Agro-Ecological Zones of Uganda

Article in Press

Propolis is a resinous plant material collected by bees to defend their colony. Unlike temperate propolis which is well studied, tropical propolis, particularly from Eastern Africa, remains largely uncharacterized. In this study, the antibacterial and antioxidant activities of Ugandan propolis were evaluated in relation to three bee-keeping agro-ecological zones of the country. Duplicate propolis samples from each...

Author(s):Julius Kyomya, Mariam Kaanyi Kirabo, Wilberforce John Mayoka, Rehema Namunyenga, Rogers Jaggwe, Lawrence Imanirampa, and Jonans Tusiimire,

Microbial and Physical Evaluation of Selected Cough Syrups Sold at Peripheral Drug Outlets in Bushenyi District, South Western Uganda

Article in Press

Syrups, being non-sterile liquid pharmaceutical formulations, are prone to microbial contamination. The most common microbial contaminants are bacteria and fungi. Contamination of oral liquid pharmaceuticals makes them hazardous due to potential to cause infections, and may also change their physical, chemical, and organoleptic properties. This study assessed the microbial quality and physical characteristic parameters of...

Author(s):Johnmary Matovu, Mark Gonahasa, Edson Ireeta Munanura, , Ibrahim Ntulume, and Jonans Tusiimire

Quality assessment of frequently available mother tinctures in the market by employing standard values

Article in Press

As general awareness for using herbal drugs in today’s health practice is increasing. The world is endorsing extraordinary increase in the consumption of herbal products. This increase in the demand has lead to consumers dissatisfaction dua to substandard products, making the herbal market risky. There is need to set standard that make evaluation of herbal drug in the formulation of high quality products. Present...

Author(s):Mahrukh Malik and Syeda Aaliya Shehzadi

Medicinal importance of garlic and onions on autonomic nervous system

Article in Press

Garlic and onion has been of medicinal value in the treatment of hypertension and it also use by people who wanted to loose weight. This research looks in to the effects of these bulbs on the entire nervous system, mechanism of action , complications of over use. This research highlights the chemistry of the active components in ,these bulbs and it role in regulating body's autonomic functions and other possible...

Author(s):Kehinde Alare, Taiwo Alare, Nallely Luviano

Examining the adherence of simvastatin prescription in diabetic patients: a descriptive study at hera general hospital makkah (HGH)

Article in Press

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. In the gulf countries specially in Saudi Arabia Diabetes type 2 is becoming the highest in the world, affecting around 30% of adults. In fact, diabetes is associated with an increased risk of cardiovascular disease (CVD). The management of diabetic dyslipidemia, a well-recognized and modifiable risk factor, is therefore a key factor in the...

Author(s):Majd Alharazi, Nouf Almalki, Hutaf Alhabashi, Rahaf Felemban, Raghad Qasim,Asala Assas, and Yosra Alhindi

Pharmacological activities of Ballota saxatilis Sieber ex C. Presl.: A short review

Article in Press

The genera Ballota (Lamiaceae family) distributed mainly in the Mediterranean area, Middle East, and North Africa. From ancient times, various species of this genera are used in traditional medicine for their biological properties such as anti-inflammatory, antimicrobial, antispasmodic, anti-malaria, insecticidal, etc. Various phytochemical investigations identified a large number of flavonoids and other metabolites and...

Author(s): Sanjay Kumar, Shailja Mishra and Reshma Kumari

Adherence to antiretroviral therapy in Kuyyu Hospital, North Shoa, Oromia region, Ethiopia

Article in Press

Good adherence to antiretroviral therapy is necessary to achieve the best virological response, lower the risk of drug resistance, and reduce morbidity and mortality. High levels of adherence (> 95%) are required for ART to be effective for long term and to prevent the emergence of resistant viral strains. The objective of this study was to assess the adherence to ART among patients on ART at Kuyyu Hospital. A cross...

Author(s):Tamirat Bekele Beressa, Anbessa Bekele

Antibiogram and Prevalence of Extended Spectrum Beta-Lactamase (ESBL)-producing E. coli and Klebsiella Species among Paediatric Patients in Abakaliki, Nigeria

Article in Press

The emergence and dissemination of extended spectrum beta-lactamase (ESBL)-producing Gram-negative bacteria is worrisome as this poses a serious threat in patient management, especially among children and the elderly. The cardinal objective of this study was to determine the antibiogram and prevalence of ESBL-producing E. coli and Klebsiella species among paediatric patients in three different healthcare institutions in...

Author(s):Iroha I. R., Ezeora C. A., Moses I. B., Onuora A. L., Kalu A. C., Ude-Ude I., Nwakaeze A. E., Ugbo E. N., Ngwu J. N., Uzoeto J. O.

Formulation of fast dissolving oral film of cetirizine hydrochloride by solvent casting method: in vitro study

Article in Press

The objective of the study was to design a fast-dissolving film of cetirizine hydrochloride (CTZHCl) by the solvent casting method using various film-forming polymers like Hydroxyl propyl methylcellulose (HPMC K4M), Polyvinyl alcohol (PVA), Sodium alginate (Na-alg). Six different formulations were designed by varying the concentration of film-forming polymer. Acquired formulations were subjected to various physicochemical,...

Author(s):Chhitij Thapa

Comparative analysis of Phytochemical Constituents and Antioxidant activity of two Pomegranate (Punica granatum L.) cultivars

Article in Press

Pomegranate (Punica granatum L.) is a well-known and widely used fruit, which contains several interesting bioactive compounds and possess health-promoting properties. Seeing the importance of this fruit, it was essential to study its quality characteristics. Hence, in the current study, we assessed total phenolic content, flavonoid content and antioxidant activity of different plant parts (leaves, rind and arils) of two...

Author(s):

Treatment outcome and associated factors among adult epileptic patients at Hawassa University Specialized Hospital, Southern Ethiopia

Article in Press

Epilepsy, once thought to be a disease of evil spirit, is now believed by many as a common neurologic condition that can be effectively treated by optimal use of anti seizure drugs. Despite the availability of multiple and cost effective medications, people with epilepsy could experience episodes of seizures. Aim of the present study was to assess the treatment outcome and associated factors among adult epileptic patients...

Author(s):

Antioxidant, Cytotoxicity, Embryotoxicity and Teratogenic Effects of Some Malaysian Medicinal Plants on SH-SY5Y cells and Zebrafish Embryos Model

Article in Press

Some Malaysian plants were extracted using 80% methanol and screened for antioxidant and toxicity effects on human neuroblastomacells line (SH-SY5Y cells) and zebrafish(Daniorerio) embryos. Antioxidant assay shows high activities with of IC50 1–100 µg/mL with Melastoma malabathricum (leaf and stem), Murraya koenigii (leaf), Curcuma longa (leaf and rhizome), Ficus deltoidea (leaf), Phaleria macrocarpa (leaf) and Ginkgo...

Author(s):

1. Quality Assessment of Analgesics Paracetamol (500 Mg) and Ibuprofen (400 Mg) for Sale in the City of Douala in Cameroon: Central Marche Case And Ndokoti.

Article in Press

Base on the findings from the Research Institute Against Counterfeit drugs (RIACD) and the Organization for Economic Cooperation and Development Drugs (OECD), 700,000 cases of death are recorded per year due to malaria and tuberculosis counterfeit drugs. According to the World Health Organization (WHO), roadside drugs kill at least 100,000 people in Africa every year, 1/3 of these drugs are counterfeit. The objective of...

Author(s):

Determination of radical scavenging activities of Acorus calamus,Prunus persica and Sassurea lappa extracts

Article in Press

Antioxidants from plants origin are considered as a promising source of biologically active substances when compared to synthetic agents who are accompanied with a number of side effects. Three botanical extracts of Acorus calamus (sweet flag), Prunus persica (peach) and Sausskurea lappa (kuth) were characterized for their antioxidant properties. Methanolic extract was prepared and concentrated by rotary evaporated. The...

Author(s):

The effects of process variables on physicochemical properties and in-vitro cytotoxic activities of 5-Fluorouracilnanoparticlesagainst Squamous cell carcinoma (SCC)

Article in Press

A 23 factorial experimental design was used to study the effects of polymer type (A), the nature of the organic phase (B) and the homogenization speed (C) on the particle sizes (S), the amount of drug entrapped (E) and the in-vitro release properties of the formulations (R). Objective This study was aimed to quantify the effects of three production variables on the physicochemical and cytotoxic activities of...

Author(s):

FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF NANOCRYSTALS OF AN ANTIBIOTIC

Article in Press

Nitrofurantoin is a broad-spectrum bactericidal antibiotic which affect both Gram-negative and Gram-positive bacteria. Nitrofurantoin exhibits bacteriostatic or bactericidal effects by inhibiting the synthesis of DNA, RNA, protein and cell wall synthesis. Nanocrystals of NFT were prepared by Cold High Pressure Homogenization technique. NFT was dispersed in aqueous surfactant solution containing Poloxamer 188, PVPK 30 and...

Author(s):

Development of a Method for Analysis of Cyclophosphamide and 4-Hydroxycyclophosphamide in Dried Blood Spot and Its Application in Therapeutic Drug Monitoring

Article in Press

Objective: To obtain optimum and validated method for simultaneous analysis of cyclophosphamide and 4-hydroxycyclophosphamide in Dried Blood Spot using Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry and its application in breast cancer patients for therapeutic drug monitoring. Methods: The separation was conducted using 1.7 μm (2.1 x 100 mm) Waters AcquityTM UPLC C18 column, mobile phase consists...

Author(s):

A pilot study to evaluate surgical antimicrobial prophylaxis in the teaching hospital: A short communication

Article in Press

Surgical antibiotic prophylaxis (SAP) administration before surgery is evidence-based practice for prevention of Surgical site infections (SSIs). The aim of study was to investigate the pattern of surgical procedures and appropriate use of SAP in teaching hospital of Islamabad, Pakistan. A one-month prospective, descriptive observational pilot study. A total of 235 surgical procedures were investigated during study period...

Author(s):

The Use of Liposomes in Clinical Applications

Article in Press

Liposomes were investigated for a long time as nanocarriers to target drugs to their sites of actions and to reduce toxicity. The unique structure of liposomes which is similar to the cellular phospholipids is considered as being an advantage to such delivery systems. Both hydrophilic and hydrophobic drugs can be encapsulated into the liposomes for delivery of a wide range of drugs such as anticancer drugs and...

Author(s):

Old and Recent Advances in Pathogenesis, Diagnosis, Prevention and Cure of Malaria Including Perspectives in Ethiopia

Article in Press

Malaria, caused by apicomplexan parasite, is an old disease and continues to be a major public health threat in many countries. This article aims to present different aspects of malaria including causes, pathogenesis, prevention and treatment in an articulate and comprehensive manner. Six Plasmodium species are recognized as the etiology of human malaria, of which Plasmodium falciparum is popular in East and Southern...

Author(s):

THERAPEUTIC EVALUATION OF QUINAPYRAMINE SULPHATE WITH FREUND’S INCOMPLETE ADJUVANT IN TRYPANOSOMA CONGOLENSE INFECTED RATS

Article in Press

Trypanosomiasis is an important protozoan disease affecting domestic livestock production in sub-Saharan Africa. Control of trypanosomiasis is by administration of antitrypanosomal drugs. Quinapyramine was widely used between 1950s and 1970s in Africa as a therapeutic and prophylactic agent in cattle. Trypanosome resistance to the drug developed rapidly and often associated with problems of toxicity. Administration of...

Author(s):

RISK FACTORS FOR MULTI DRUG-RESISTANT TUBERCULOSIS AMONG TUBERCULOSIS PATIENTS OF NEKEMTE REFERRAL HOSPITAL, OROMIA REGIONAL STATE, WESTERN ETHIOPIA, 2017.

Article in Press

Multidrug-Resistance Tuberculosis (MDR-TB) is tuberculosis (TB) that is resistant to two first-line drugs; both isoniazid and rifampicin. Globally in 2015, there were an estimated 480, 000 new cases of multidrug-resistant TB. According to the anti-tuberculosis drug resistance survey conducted nationwide in Ethiopia in 2012 among 804 newly diagnosed TB cases 1.6 % were found to be infected with MDR-TB. The continuous...

Author(s):

Effect of Chronic Alcohol Exposure and Abstinence on Metabotropic Glutamate Receptor Subtype 5 Binding in Brains of C57BL/6J Mice

Article in Press

Metabotropic glutamate receptor subtype 5 (mGluR5) is involved in the transition of alcohol use to addiction by activating signalling pathways and inducing glutamate excitotoxicity. The objective was to investigate the effects of chronic alcohol treatment and withdrawal on mGluR5 binding in the brains of C57BL/6J mice. The study was a controlled experiment in which male C57Bl/6J mice were introduced to the alcohol liquid...

Author(s):

Prokinetic effect of ferulic acid ethyl ester on mice

Article in Press

Gastrointestinal (GI) diseases are public health problem which affects 69% of the world's population. Among the disorders that cause gastrointestinal hypomotility is mainly constipation, but drugs available for the treatment of this disorder come with numerous adverse effects, among them the most common are abdominal pain and cardiotoxic potential. Ferulic acid ethyl ester (FAEE) is a phenylpropanoid widely found in...

Author(s):Izabela Borges de Carvalho Lima

Synthesis, antibacterial and anticancer activities of some novel 2-substituted aminothiazoles

Article in Press

Amino group of thiazole moiety (26) was treated with various aromatic aldehydes its gave corresponding Schiff's bases (27-36). These Schiff's bases were reacted with benzyl in the presence of ammonium acetate (NH4OAc) to find corresponding novel 2-substituted aminothiazoles (37-46). Structures of all the newly synthesized compounds were confirmed by IR, 1H NMR, mass spectral data and elemental analysis. The synthesized...

Author(s):Thiazoles, aminothiazoles, antibacterial activity, anticancer activity.

Effects of commercial herbal preparation (hp) used in Nigeria on lipid profile of acetaminophen-intoxicated rats

Article in Press

This study evaluated the protective effects of commercial herbal preparation (HP) on acetaminophen (APAP) induced lipid profile aberrations in rats. Twenty four male rats were divided into 6 groups of 4 rats each and treated orally as follows: Group 1 (normal control), group 2 (intoxicated and untreated), group 3 (pre-treated with 100 mg/kg b.w. of silymarin), groups 4, 5 and 6 (pre-treated with 1, 2 and 3 ml/kg b.w. HP)...

Author(s):Pharmacological Biochemistry Unit, Department of Biochemistry, University of Nigeria, Nsukka, Nigeria

Synthesis, Biological Evaluation and Molecular Modeling of Hybrid Compounds based on Different Fragments Clubbed with Pyrrole

Article in Press

The limitations of currently available drugs and emergence of multidrug and extensively drug-resistant strains of Mycobacterium tuberculosis (Mtb) stress the need of new candidates as antitubercular agents. Different 2,5-dimethyl pyrrole derivatives clubbed with coumarin, naphthyl, furyl, phenyl, fragment of ibuprofen, fragment of diclofenac were synthesized and evaluated for antitubercular activity. The structure of all...

Author(s):Apeejay Stya University, Haryana

GLUCOSINOLATES: TAME PRECURSORS – POTENT PRODUCTS-A REVIEW

Article in Press

Cruciferous vegetables constitute an important phytochemical that is Glucosinolate, it is an organic anionic compound containing sulphur, nitrogen and a group derived from glucose. Glucosinolates are abundantly present in the members of family Cruiciferae. The enzymes catalysing the hydrolysis of glucosinolates are known as myrosinases. The potentially beneficial activities of glucosinolates and their enzymatic hydrolysis...

Author(s):

Isolation and Antimicrobial Efficacy of Bergenia ciliate Using in vitro Models

Article in Press

Antimicrobial activities of five constituents isolated from ethyl acetate fraction of Bergenia ciliate were investigated. About all constituents exhibited antimicrobial efficacy on the tested microorganisms, including two human Gram-positive bacteria (Staphylococcus aureus, Micrococcus luteus) and four Gram-negative ones (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella Pneumonia). Of these...

Author(s):Collage of Material Science, Beijing University of Chemical Technology, Beijing, China

Film forming Gels: A Review

Article in Press

Film forming gels are a novel approach in this area that might present an alternative to the conventional dosage forms used on the skin, such as ointments,creams, gels or patches. The polymeric solution is applied to the skin as a liquid and forms an almost invisible film in situ by solvent evaporation. Transdermal drug delivery system (TDDS) can provide some desirable performances over conventional pharmaceutical dosage...

Author(s):department of pharmaceutical sciences, Kumaun University, Nainital

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