July 2017

Role of Meloxicam as a selective inhibitor of COX-2 in the inhibition of Ehrlich solid tumor growth

High levels of cyclooxygenase (COX) enzymes and its metabolites, especially prostaglandin E2 (PGE2) are generated in inflammatory conditions and, eventually, can contribute to neoplasms growth, justifying, in certain malignancies. COX occurs in two major isoforms, physiologically as isoform COX-1 and during inflammation as COX-2. In certain neoplasms, benefits are reported with the use of the selective COX-2 inhibitor...

Author(s): Dulce Helena Jardim Constantino⊃, Bruno Henrique Serotini⊃ and Mariza Akemi Matsumoto⊃