March 2015

The role of nitric oxide in alendronate-mediated acceleration of gastric emptying and gastrointestinal transit in rats

The effect of the alendronate (ALD; 30 mg/kg, pH 7.0, p.o.) and sodium nitroprusside (SNP; 10 mg/kg, p.o.; a nitric oxide (NO) donor) on gastric dye retention (GDR) and proximal, medial and distal small intestine dye retentions (IDR) was investigated in rats. The drugs were administered once daily for 4 days. On the last day of treatment, 4 h after ALD administration, GDR and IDR were measured. ALD treatment decreased...

Author(s): Renan Oliveira Silva, Rudy Diavila Bingana, Pedro Marcos Gomes Soares, Marcellus Henrique Loiola Ponte Souza and Jand Venes Rolim Medeiros,

March 2015

An analysis of the quality of studies that evaluate potentially inappropriate drug therapy

In the elderly population, increased predisposition to chronic diseases and consequent use of various medications increases the chances of using a potentially inappropriate drug therapy. The purpose of this review was to analyze research that uses tools to study potentially inappropriate drug therapy through the strengthening the reporting of observational studies in epidemiology (STROBE) initiative. A systematic review...

Author(s): Ana Patrícia Alves Lima Santos, Daniel Tenório Silva, Vanessa Alves Conceição, Carina Carvalho Silvestre, Divaldo Pereira de Lyra Jr. and Angelo Roberto Antoniolli

March 2015

Suspending properties of natural gums extracted from Abelmuscus esculentus pod and Chrysophyllum albidium fruit

The aim of this study was to extend the application of gum extracted from Abelmuscus esculentus pods (AEG), ripped Chrysophyllum albidium fruit (RCAG) and unripped C. albidium fruit (UCAG) to pharmaceutical suspensions. The extracted gums, gelatin and compound tragacanth were used to formulate Paracetamol suspension in concentrations of 0.5 to 4.0% w/v. The sedimentation rates, sedimentation volume, ease of...

Author(s): Bakre Lateef Gbenga and Ajakore Oluwabunmi

March 2015

Potential antimicrobial and antiproliferative activity of the crude extract of the endophytic fungus Rhizoctonia sp. from Annona crassiflora

One hundred and twelve (112) endophytic fungi was isolated from leaf fragments of Annona crassiflora. Extracts were prepared by fermentation in Czapek broth. The extract of endophytic fungus Rhizoctonia sp. was selected as the most promising from an antimicrobial screening and its ability to produce metabolites with antimicrobial and antiproliferative activity was evaluated. Antimicrobial activity was evaluated through...

Author(s): Andrea Natan de Mendonça, Bárbara Helena Muniz Padro e Feliphe, Raquel Maria Lima Lemes, Ana Lúcia Tasca Gois Ruiz, João Ernesto de Carvalho  and Masaharu Ikegaki

March 2015

Teaching in pharmaceutical care: A systematic reviewTeaching in pharmaceutical care: A systematic review

The aim of the work was to systematically review published studies about teaching methods in pharmaceutical care. Literature databases searched included LILACS, PubMed, SCOPUS, EMBASE, and ERIC. Studies published until January 2015 were searched for using the search terms “pharmaceutical services”, “pharmaceutical care”, “medication therapy management”, “learning”,...

Author(s): Werlissandra Moreira de Souza, Alessandra Rezende Mesquita, Angelo Roberto Antoniolli, Divaldo Pereira de Lyra Júnior and Wellington Barros da Silva

March 2015

Possible cardio-protective effect of ginger and lipoic acid on normal senile female rats

Cardiovascular disease and oxidative stress are involved in aging. Aging causes many alterations in myochardial functions and metabolism. The aim of this study was to investigate the effect of aging on heart functions, total antioxidant capacity and membrane lipid composition and the effects of oral administration of ginger and lipoic acid for 30 days. The levels of serum lactate dehydrogenase, creatine kinase and heart...

Author(s): Rehab M. Mosaad and Hend A. Sabry