November 2015

Gender-related differences in pharmacokinetic parameters of tramadol following intravenous and subcutaneous administration in dogs

The kinetics of tramadol at 3 mg/kg was studied in twenty four local dogs (twelve males and twelve females), after a single intravenous and subcutaneous dose administration. Three milliliters of blood from the jugular vein were collected before and at 2, 5, 10, 15, 30 and 45 min, 1, 1.5, 2, 2.5, 3, 4, 6, 8 and 9 h post administration of tramadol from both groups with the exception of 2 min for subcutaneous group. The...

Author(s): Buhari Salisu, Kalthum Hashim, Goh Yong Meng and Gan Siew Hua

November 2015

Synthesis of Cu(II) complex with schiff bases derived from aryl-S-benzyildithiocarbazate: Antimicrobial activity and in silico biological properties evaluations

This study reported the synthesis of the new ligands, 3,4-methylenedioxybenzyl-S-benzyldithiocarbazate (L1), p-chloro-benzyl-S-benzyldithiocarbazate (L2) and 2,6-dichlorobenzyl-S-benzyldithiocarbazate (L3).  These three schiff base type ligands were respectively obtained by means of the reaction of 3,4-methylenedioxybenzaldehyde, p-chlorobenzaldehyde and 2,6-dichlorobenzaldehyde with S-benzyldithiocarbazate, at...

Author(s): K. G. O. Casas, M. L. G. Oliveira, G. D. de Fátima Silva, C. J. Viasus  and A. E.  Burgos