African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 22 January, 2012; 6(3)

January 2012

Evaluation of chemical constituents of Phyllanthus Niruri

The study was carried-out to evaluate the chemical constituents of Phyllanthus niruri, a commonly multifunctional activities herbal plant used for curing different ailment. The plant (roots, leafs and stem) was collected in Federal Capital Territory Abuja, Nigeria in the months of July to August, 2009 and used throughout the study. Phytochemical, elemental and physicochemical constituents of the plant was...

Author(s): Samali, A., Florence, D. T., Odeniran, O. A. and Cordelia O.N.

January 2012

Apoptosis induced in human breast cancer cell line by Acanthaster planci starfish extract compared to tamoxifen

Breast cancer remains the most common cancer among women all over the world. Current chemotherapeutic drugs for breast cancer such as tamoxifen show severe side effects. Therefore, there is a focus toward new chemotherapeutic agents to be obtained from natural sources. This study was carried out to evaluate cytotoxic and apoptotic effects of theAcanthaster planci starfish extract compared to tamoxifen in human...

Author(s): Ahmed Faisal Mutee, Salizawati Muhamad Salhimi, Farid Che Ghazali, Faisal Muti Al-Hassan, Chung Pin Lim, Kamarruddin Ibrahim and Mohd Zaini Asmawi

January 2012

Simultaneous spectrophotometric determination of nitroanilines using genetic-algorithm-based wavelength selection in principal component-artificial neural network

Ternary mixtures of nitroaniline isomers have been simultaneously determined in synthetic and real matrix by application of genetic algorithm principal component artificial neural network model. All effective factors on the sensitivity were optimized. Also, the linear dynamic range for determination of nitroaniline isomers was found. The simultaneous determination of nitroaniline mixtures by using spectrophotometric...

Author(s): Mohammad Goodarzi, Ashok Kumar Malik and Nasser Goudarzi

January 2012

Evaluation of inorganic profile and anti-nutritional values of Cocculus hirsutus

As the plants are directly in contact with air, water and soil, the constituents of these sources might contaminate the plants. Useful elements, such as Na, K, Ca, Mg, P, Fe, Cu and Co are also usually present in plants which help in good health. Cocculus hirsutus, belongs to the family Menispermaceae and it is a perennial climber mainly used for the treatment of diabetes, laxative, demulcent, anti...

Author(s): Farhat Ali Khan, Asfandyar Khan, Muneeb Ur Rehman Khattak, Naseem ullah, Muhammad Zahoor and Syed Muhammad Mukaram Shah

January 2012

Biomechanical evaluation of fracture healing following administration of Piper sarmentosum in ovariectomised rats

The influence of osteoporosis on fracture healing is a complex phenomenon. Oxidative stress is considered as a pathogenic factor for bone loss and delayed fracture healing. Piper sarmentosum is known to possess an antioxidant and anti-inflammatory properties. This study aimed to investigate the fracture healing properties of P. sarmentosum aqueous extract in ovariectomised rats by observing changes...

Author(s): Mohamed Abdalla Estai, Farihah Suhaimi, Ahmad Nazrun Shuid, Srijit Das, Shahrum Abdullah and Ima-Nirwana Soelaiman

January 2012

Protective effects of various fractions of Launaea procumbens on molecular markers in rat kidney

Molecular markers; DNA, argyrophilic nucleolar organiser regions (AgNORs) and telomerase enzymes play important role in diagnosis of nephrotoxicity induced by potassium bromate (KBrO3). In the present study, the effects of Launaea procumbens against KBrO3 induced molecular changes in male rats are determined. 36 male albino rats (180 to 200 g) were divided into 6 groups. Group I was given saline...

Author(s): Rahmat Ali Khan, Muhammad Rashid Khan, Sumaira Sahreen, Naseer Ali Shah, Amir Muhammad Khan, Jasia Bokhari, Umbreen Rashid, Bushra Ahmad, Maria Shabbir, Naima Saeed, Shumaila Jan and Tayyaba Afsar

January 2012

Stability, content uniformity and therapeutic efficacy of sildenafil extemporaneous capsules

Sildenafil extemporaneous formulations, used to treat pulmonary arterial hypertension (PAH) in hospitalised children, must be also stable and uniform in content. In this study, we determinedcontent uniformity, stability and therapeutic efficacy of sildenafil in gelatine capsules containing5 mg from three brands (Viagra®, Maxifort® and Apodefil®). The powder from...

Author(s): Blanca Ramírez-Mendiola, Liliana Rivera-Espinosa, Juan Luis Chávez-Pacheco, Radamés Alemón-Medina, Jesús Bobadilla-Chávez, Héctor Osnaya-Martínez, Carmen Flores- Pérez., Hugo Juárez-Olguín, Janett Flores-Pérez and Raquel García-Alvarez

January 2012

Changes in nitric oxide levels and erythrocyte arginase activities in patient with Down syndrome

Down syndrome is a chromosome abnormality with specific clinical symptoms and mental retardation caused by trisomy of chromosome 21. There is evidence that oxygen free radicals play an important role in the pathophysiology of many neuropsychiatric disorders. Although, it has not been investigated yet, several recent studies proposed that nitric oxide related to oxidative stress and arginase may have a...

Author(s): Ulku Ozbey, Ayse Seyran, Mine Erisir, Fulya Benzer and Yuksel Savucu

January 2012

Qianliening capsule treats benign prostatic hyperplasia through regulating the expression of sex hormones, estrogen receptor and androgen receptor

The objective of the study to evaluate the effect of Qianliening capsule (QLNC) on the expression levels of serum hormones, prostatic estrogen receptor and androgen receptor in benign prostatic hyperplasia (BPH) rats, and investigate the possible molecular mechanisms mediating its anti-BPH activity. Male Sprage-Dawley (SD) rat BPH model was generated. BPH rats were orally treated with different concentrations of QLNC....

Author(s): Jianheng Zhou, Jiumao Lin, Xu Wei, Xiaoyong Zhong, Yuqing Zheng, Zhenfeng Hong and Jun Peng

January 2012

n-Acetylcysteine for prevention of iodinated contrast-induced nephropathy in computed tomography angiography procedures in patients with chronic kidney disease

N-Acetylcysteine (NAC) is used in the prevention of contrast-induced nephropathy (CIN) in our institution. The variation in clinical effects as a result of dosage differences between intravenous (IV) and oral administration warrants further investigation. This study primarily aimed to evaluate the incidence of CIN in patients with renal impairment, comparing those who received IV NAC with those receiving oral NAC. This...

Author(s): Cheang Cheng Ye, Endang Kumolosasi and Chua Eng Wee

January 2012

Cyclo[(-D-Gly3-L-Asp3)] in combination with C and D polypeptide chains of NS3; suggestion a novel nanoparticle to stimulate immune system against hepatitis C

Development of a hepatitis C vaccine is a challenge. Although several vaccines are currently under development, no effective vaccine is currently available. Non structural protein- NS3- can stimulate TH1 and make enhancement in NS3-specific interferon-γ (IFN-γ) serum level. It is thought to use nanoparticles which are biodegradable and safe to body can be a novel approach to deliver...

Author(s): Babak Khalili Hadad, Hadis Soltani, Sara Nouroozi and Fatemeh Navaie

January 2012

Physico-chemical properties of Blighia sapida (ackee) oil extract and its potential application as emulsion base

Oil extracted from the ripe ackee (Blighia sapida L) aril was characterized by the classical titrimetric and gravimetric analyses following the British Pharmacopoeia (BP) procedures. Dynamic and kinematic viscosities as well as the true density of the lipid were determined. The sample was subjected to instrumental polarimetric and gas chromatographic analyses. In each test, arachis oil (BP) and/or oleic acid was...

Author(s): Elizabeth Naomi Anderson-Foster, Amusa Sarafadeen Adebayo, and Nilza Justiz-Smith

January 2012

Antidepressant-like activities of Ocimum basilicum (sweet Basil) in the forced swimming test of rats exposed to electromagnetic field (EMF)

Medicinal use of basil, Ocimum basilicum, dates back to ancient times in Iran, China and India. In this study, we aimed to experiment on the antioxidative property of a herbal source (sweet basil) to protect central nervous system against oxidative damages of electromagnetic field (EMF) and it’s affective sequences. We used forced swimming test to evaluate antidepressant effect of basil extract in 30 albino...

Author(s): Mehdi Abdoly, Alireza Farnam, Fatemeh Fathiazad, Arash Khaki, Amir Afshin Khaki, Arezoo Ibrahimi, Fatemeh Afshari and Hossien Rastgar

January 2012

Effect of endurance exercise training on blood lipids in young men

The present study was conducted in order to investigate the effect of aerobic exercise (running) performed regularly for eight weeks without a special diet on blood lipid and lipoprotein levels. Twenty non-smoker, moderately active young volunteer men who were not on a special diet (Training Group = 10 and Control Group = 10) participated in the study. Training group performed aerobic exercise at target heart beat rate...

Author(s): Nazmi SARITAÅž

January 2012

An evaluation of Pakistani pharmacy students’ knowledge of herbal medicines in Pakistan

The objective of study was to evaluate the knowledge of students on herbal medicines in Pakistan. To evaluate knowledge among the students, a questionnaire based study about herbal medicines was designed. Mean age of responding students was 22 years, some of them had used herbal medicines in past and some were still using. Majority of the students were interested in the information related to herbal medicines. The...


January 2012

Visio Scan® VC98, Corneometer MPA 5 and Tewameter MPA 5

Human skin is the largest exposed area of our body. There are number of physiological changes which may occur in response to internal or external sources. Biophysical techniques have been extensively employed to study any changes in human skin physiology. Usually these bioengineering techniques are equipped with non-invasive probes. Visioscan, Corneometer and Tewameter are the most widely used techniques in the...

Author(s): Barkat Ali Khan, Naveed Akhtar, Khalid Waseem, Tariq Mahmood, Akhtar Rasul, Muhammad Iqbal and Shahiq-uz-Zaman