January 2014

Formulation and evaluation of binary and ternary solid dispersions of domperidone by solvent evaporation method

First-pass metabolism affects many oral medications and limits the attainment of their therapeutic level. It can be bypassed by administrating buccal dosage forms that allow systemic drug absorption via buccal mucosa. Drugs formulated as buccal medicaments should have an acceptable solubility in saliva. Numerous technologies had been experimented to increase the aqueous solubility of poorly water-soluble drugs e.g....

Author(s): Dina Mahmoud Abd Alaziz, Omaima Ahmed Sammour, Abd Elhameed Abd Allah Elshamy and Demiana Ibrahim Neseem

January 2014

Improving effect of zinc supplementation on pituitary gonadotropins secretion in smokers

This study aimed to investigate the effect of zinc supplementation on testicular tissue as a feed-back mechanism of the pituitary secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) on cigarette smoker subjects. Total of twenty subjects participated in this study as per the national bioethics committee guidelines. Venous blood samples were collected for determination of serum level of LH and FSH...

Author(s): Mohamad S. Bakheet⊃ and Hassan A. Almarshad⊃

January 2014

The suspending properties of Terminalia randii gum in magnesium carbonate suspension

Terminalia randii tree is widely planted in Nigeria as an exotic plant, and gum can be obtained from the incised trunk. The natural gum from T. randii is a hydrophilic carbohydrate polymer. The purpose of this work was to develop cheap and effective natural excipient that can be used as an alternative for the formulation of pharmaceutical suspensions. The suspending properties of T. randii gum (Combretaceae) was studied...

Author(s): Bamiro Oluyemisi Adebowale, Ajala Tolulope Omolola, Uwaezoke Onyinye Jennifer and Akinwunmi Abidemi Gbemisola