August 2015

Seeking efficacy in L-asparaginase to combat acute lymphoblastic leukemia (ALL): A review

L-asparaginase, a potential anti-leukemic drug, is used in clinics for the treatment of childhood acute lymphoblastic leukaemia, and is obtained from bacterial origin (Escherichia coli and Erwinia carotovora). The efficacy of L-asparaginase has remained under discussion for bearing many limitations, such as, early clearance from blood plasma and therefore requires multiple administration and various side effects causing...

Author(s): Ali Usman

August 2015

Comparative study of analgesic and anti-inflammatory effects of Commiphora opobalsamum with diclofenac in rodents

This study aims to investigate the analgesic and anti-inflammatory effects of Commiphora opobalsamum in rodents in comparison with diclofenac, and its ability to enhance the activity of diclofenac in reduced doses. Wister rats or Swiss mice (5 groups/ 6 each) were administered methalonic extract of C. opobalsamum, saline and diclofenac 30 min before the test initiation by i.p. route. The analgesic activities were...

Author(s): Akram A. Al-Salmi, Mai A. A. A. Sattar, Lateef M. Khan, and Sameer E. Al-Harthi

August 2015

Pharmacotherapy follow-up in elderly in a public outpatient clinic in Brasilia, Brazil

The aging process is followed by an increase in the number of chronic diseases and, thus, the use of multiple medicines and prevalence of drug-related problems (DRP). This paper aims to identify the impacts of Pharmacotherapy follow-up (PF) in elderly with chronic non-communicable diseases while in polypharmacy using, in the public health service of Brazil. A prospective cohort study with 45 elderly of both sexes was...

Author(s): Mirna Poliana F. Oliveira and Maria Rita C. G. Novaes