February 2015
Formulation, optimization and characterization of candesartan cilexetil nanosuspension for in vitro dissolution enhancement
According to Biopharmaceutical classification system (BSC), candesartan cilexetil (CC) is a class-II drug which has limited bioavailability mainly due to its low solubility. In order to enhance its solubility, a universal approach of making nanosuspension is been used in the present investigation. High pressure homogenization, controlled precipitation, media milling and high speed homogenization are the various...
February 2015
Muscarinic activity of aqueous leaves extract of Excoecaria grahamii Stapf 1913 on rabbit blood pressure and toad isolated perfused heart
Excoecaria grahamii, African shrub, is used in many West African countries traditional medicine against different diseases as powerful purgative and biopesticide. There is little work about pharmacological effects of this plant because of its high toxicity. The effects of the aqueous extract of the plant was investigated on rabbit blood pressure and toad isolated and perfused heart activity. E. grahamii extracts (EGE)...
February 2015
Ethnobotanical survey of anticancer plants in Askira/Uba local government area of Borno State, Nigeria
Ethnobotanical survey was conducted on anticancer plants in Askira/Uba local government area of Borno State, Nigeria. Administration of questionnaires and oral interviews to 20 traditional medicine practitioners (TMPs) and field trip were carried out in the study area. A total of 65 different plants belonging to 41 families were identified during the survey. Six plants belong to the Caesalpinioideae, 5 from Fabaceae, 4...
February 2015
Physicochemical characterization of lapachol
The aim of this study was to characterize three batches of lapachol (LAP), in order to establish specifications for the development of pharmaceutical forms. Physical methods including nuclear magnetic resonance (1H and 13C NMR), infrared spectroscopy (IR), scanning electron microscopy (SEM), x-ray diffraction, differential scanning calorimetry (DSC), determination of the melting range and drug assay were performed. All...
February 2015
Methanolic extracts from roots and cell suspension cultures of Waltheria americana Linn induce GABA release in cerebral slices of mouse brain
This study evaluates and compares the release of the neurotransmitter γ-aminobutyric acid (GABA) induced by methanolic extracts obtained from roots of wild plants and from cell suspension cultures of W. americana Linn. The release of this neurotransmitter was evoked by crude and fractioned extracts derived from both roots of wild plant and cell suspension cultures, tested at three concentrations: 10, 50 and 100...
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