July 2014

Potential involvement of oxidative stress in induction of neurodegenerative diseases: Actions, mechanisms and neurotherapeutic potential of natural antioxidants

Several studies have shown that oxidative damage to various organs of a given organism is involved in causing various diseases, and in this context, the brain is highly vulnerable to oxidative stress because of its high metabolic rate, low capacity of cell regeneration, small amounts of enzymatic and non-enzymatic antioxidants. Oxidative stress is caused by an imbalance in cell redox state, in which there is excessive...

Author(s): George Laylson da Silva Oliveira, Francisco Rodrigo de Asevedo Mendes de Oliveira and Rivelilson Mendes de Freitas

July 2014

Synthesis of some new [1,3,4]oxadiazine-[6,5-b]indole derivatives and their biological activity

Novel 2-[(benzalamino-4-hydroxybenzyl) [1,3,4]-oxadiazino[6,5-b]]indole derivatives (V1-21) were synthesized via a simple condensation reaction between 2-Amino-4-([1,3,4]-oxadiazino-[6,5-b]indole-3-yl)-phenol (IV) and challenging aromatic aldehydes. The compound IV was synthesized by an acid catalyzed cyclization of 3-amino-4-hydroxy-benzoic acid (2-oxo-1,2-dihydro-indol-3-ylidene)-hydrazide (III). Thus produced final...

Author(s): Tumma Soujanya and Srinivas Kantham