March 2014

Toxicological evaluations of ethanolic crude seed extract of Corchorus olitorius

The toxicological effect of the ethanolic seed extract of Corchorus olitorius was evaluated in white albino rats as a prelude to further pharmacology assessment of the plant seed extract. The acute, sub acute and chronic effects of the extract following oral administration in the animal were studied. The lethal medium dose (LD50) of the extract was estimated to be higher than 5000 mg/kg. Oral administration of 250, 500...

Author(s): Maxwell Osaronowen Egua, Emmanuel Udo Etuk, Shaibu Oricha Bello and Sanusi Wara Hassan

March 2014

Development and in-vitro characterization of lornoxicam loaded ethyl cellulose microspheres prepared by emulsion solvent evaporation method

Advancement in drug delivery could come from innovating improvement to the existing drug delivery system. Lornoxicam (Lxm) loaded ethyl cellulose microspheres were prepared by emulsion solvent evaporation technique and also to investigate the effect of variations in drug concentration, polymer concentration, internal phase volume, continuous phase volume and emulsifier concentration on the particle size, shape, % yield,...

Author(s): Lalit Kumar Tyagi and Mohan Lal Kori

March 2014

Preparation of magnetic microspheres of mesalamine by phase separation emulsion polymerisation technique

The study involved magnetic microspheres of mesalamine prepared by phase separation emulsion polymerization (PSEP) method technique. Magnetic microspheres were prepared by PSEP method to target them to the colon. Three polymers namely Eudragit S 100, ethylcellulose and chitosan were used for the preparation of magnetic microspheres. Magnetite content and entrapment of mesalamine was evaluated. Eudragit S 100,...

Author(s): Satinder Kakar and Ramandeep Singh