African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2276

Table of Content: December; 4(12)

December 2010

Anticarcinogenic effect of turmeric on processed food products containing acrylamide

In present scenario Acrylamide concentration in processed food products have become a very serious health issue. The World Health Organization (WHO) and The Scientific Committee for Food (SCF) of the European Union also confirmed this concern. In laboratory scale, it was found that Acrylamide causes tumors in animals. It is even present in processed food free of microbes indicating the absence of microbial role in...

Author(s): Akshaya Pandey, Prateek Garg and R. Balaji Raja

December 2010

Activity induced by dihydrotestosterone-dihydropyrimidine derivative on perfusion pressure and coronary resistance in isolated rat heart

Experimental and clinical studies suggest that dihydrotestosterone can be associated with changes in blood pressure. In this work, the effects induced bydihydrotestosterone and dihydrotestosterone-dihydropyrimidine on perfusion pressure and coronary resistance were evaluated, in isolated rat heart using the Langendorff flow model. Additionally, the molecular mechanism involved in the activity...

Author(s): Figueroa-Valverde Lauro, Díaz-Cedillo Francisco, Lopez-Ramos Ma, Garcia-Cervera Elodia and Quijano A. Karen

December 2010

Screening for anti-typhoid activity of some medicinal plants used in traditional medicine in Ebonyi state, Nigeria

Ethanol, hot and cold crude water extracts of five medicinal plants namely Vitex doniana (root), Cassia tora (Leaf), Alstonia boonei (bark), Stachytarpheta  jamaicensis(leaf), and Carica papaya (leaf) used as traditionally medicine for anti Salmonella typhiactivity in Ebonyi state were evaluated. These plants were screened in-vitro for anti-typhoid activity against...

Author(s): Iroha I. R., ILang D. C., Ayogu T. E., Oji A. E. and Ugbo E. C.

December 2010

Role of glucocorticoid receptor and nuclear factor kappa B in rat hepatic injury after traumatic hemorrhagic shock

The present study investigated expressions and functions of glucocorticoid receptor (GR) and nuclear factor kappa B (NF-B) in rat livers after traumatic hemorrhagic shock. The rat model of bilateral femur fracture accompanied with traumatic hemorrhagic shock was established. 96 male Wistar rats were randomly divided into normal control group (n = 6), traumatic shock group (n = 30), GR blocking group (n = 30) and...

Author(s): Donglin Luo, Xiankai Huang, Baohua Liu, Xiaobao Ren, Renping Xiong, Tao Li and Guangyan Li

December 2010

Beneficial effect of taurine in spontaneous hypertensive rats: Implication of its antioxidant activity

Taurine, a sulfur-containing amino acid, has been reported to play an antihypertensive role but the mechanism underlying this activity is yet to be defined. In this study, we investigate the effect of taurine on blood pressure by oral administration in conscious spontaneously hypertensive rats (SHR). Total heart weight, left ventricular weight, lipid peroxidation as well as glutathione (GSH) and superoxide dismutase...

Author(s): R. Chahine, J. Hanna, C. Bassil, N. Rihana, A. Mounayar and H. Greige

December 2010

Aerodynamic characterization of marketed inhaler dosage forms: High performance liquid chromatography assay method for the determination of budesonide

A sensitive and rapid high performance liquid chromatography method was developed and validated for the determination of aerodynamic characteristics of the emitted dose of budesonide from different inhaler dosage forms. The mobile phase consisted of a mixture of acetonitrile and 10 mM ammonium acetate (63:37% v/v) adjusted to pH5 with orthophosphoric acid. The HPLC analysis was performed at a flow rate of 1 mL/min using...

Author(s): Mohanad Naji Sahib, Yusrida Darwis, Peh Kok Khiang and Yvonne Tze Fung Tan

December 2010

Effect of Aloe vera (Aloe barbadensis) gel extract on re-polarization state of myocardium in albino rat

Aloe vera is a well known medicinal plant contents with over 75 different ingredients,anthraquinones, saponins, and sterols. Recent studies showed that it is a potent hypolipedimic, hypoglycemic and antioxidant. In present study we investigated the dose dependent effect of aloe vera gel on  repolarization state of myocardium, heart rate, QRS complex and QT interval using electrocardiograph  in albino rats. A...

Author(s): Pradeep Kumar, Sadhana Verma, Shraddha Singh, Sunita Tiwari and M. Y. Khan

December 2010

A comparison of blood lipid levels of physical education and sports school students attending to different curriculum

This study has been conducted in order to determine the impact of applied courses on the blood lipid levels of male and female students enrolled at the different departments of School of Physical Education and Sports by a comparison of blood lipid levels; having 30 male and 30 female students volunteered for the study – a total of 60 students – whose average age was 20±2,5 years. Any exercise program...

Author(s): Hürmüz Koç

December 2010

Isolation, identification and characterization of bacteriocin from Lactobacillus lactis and its antimicrobial and cytotoxic properties

Bacteriocin produced by Lactobacillus lactis strain isolated from the marine environment, showed broad range of antibacterial activity against some major food borne pathogens. Maximum bacteriocin production was observed at 30°C, pH 6.0 and 1.5% sodium chloride solution. The enzymes α-amylase, DNase, RNase and lipase had a positive effect on bacteriocin production. Proteinase K and pepsin strongly...

Author(s): G. Rajaram, P. Manivasagan, U. Gunasekaran, S. Ramesh, S. Ashokkumar, B. Thilagavathi and A. Saravanakumar

December 2010

Identification of a bacterium that produced an anti-mycobacterium tuberculosis activity

The colonial morphology, the cells and the spores of a bacterium had been observed that could produce an anti-Mycobacterium tuberculosis antibiotic. By physiological and biochemical characteristics and by 16S rDNA analysis, this bacterium was identified asBacillus subtilis.   Key words: Bacterium, identification, 16S rDNA, Bacillus subtilis.

Author(s): Chen Xiaoxi

December 2010

In vitro time-kill studies of antibacterial agents from putative marine Streptomyces species isolated from the Nahoon beach, South Africa

We assessed the antibiotic production potentials of ten putative Streptomyces strains isolated from the Nahoon beach and their antibacterial activities against a wide range of bacteria including reference strains, environmental strains and clinical isolates. The minimum inhibitory concentrations (MICs) of the crude ethyl acetate extracts ranged from 0.039 to 10 mg/mL and the least minimum bactericidal...

Author(s): Isoken H. Ogunmwonyi, Ntsikelelo Mazomba, Leonard Mabinya, Elvis Ngwenya, Ezekiel Green, David A. Akinpelu, Ademola O. Olaniran and Anthony I. Okoh