May 2024

Clinical and parasitological evaluation of cutaneal lesions in Mesocricetus auratus infected with Leishmania amazonensis

Cutaneous leishmaniasis is an infectious-parasitic disease that is vector-transmitted by female Phlebotomus species through a blood meal. The drugs recommended by the Ministry of Health show moderate efficacy and numerous adverse reactions, making it necessary to develop new drugs. However, it is essential to establish new and vibrant diagnostic techniques detecting and quantifying the parasites in experimental animals...

Author(s): Bruno Bezerra Jensen, Claudia Dantas Comandolli-Wyrepkowski, José Fernando Marques Barcellos, Aline Fagundes da Silva, Paula Figliuolo da Cruz Borges, Rebecca Sayuri Barbosa Hanada, Francimeire Gomes Pinheiro, and Antonia Maria Ramos Franco  

May 2024

An in vitro evaluation of the antileishmanial and cytotoxic activity of methyl gallate associated with conventional treatment for cutaneous leishmaniasis

Cutaneous leishmaniasis (CL) is a non-contagious infectious-parasitic disease caused by protozoa of the genus Leishmania sp. It is considered a neglected tropical disease and involves public health issues because it affects socially vulnerable populations. The therapy recommended by the Brazilian Ministry of Health as the standard treatment for CL presents numerous challenges. Therefore, it is necessary to look for...

Author(s): Rebecca Sayuri Barbosa Hanada, Bruno Bezerra Jensen, Richaelly Pinheiro dos Santos, Paula Figliuolo da Cruz Borges, Francimeire Gomes Pinheiro, Mayara Arguello da Silva, Ana Caroline dos Santos Castro, Juliana Maria de Morais and Antonia Maria Ramos Franco  

May 2024

Evaluation and validation of limited sampling strategy for estimating individual exposure of mycophenolic acid in renal transplant children receiving concomitant tacrolimus

Limited sampling strategies (LSS) for estimating the area under the concentration-time curve (AUC) of mycophenolic acid (MPA) in renal transplant children receiving concomitant tacrolimus have been developed, but they have not yet undergone full validation. The objectives of the present study were to evaluate the predictive performance of previously published LSS of MPA in an independent pediatric population and to...

Author(s): BROU Nguessan Aimé, TE BONLE Leynouin Franck-Olivier, BALAYSSAC Eric, N’ZOUE Kanga Sita and SANGBEU Bertrand