May 2024
Clinical and parasitological evaluation of cutaneal lesions in Mesocricetus auratus infected with Leishmania amazonensis
Cutaneous leishmaniasis is an infectious-parasitic disease that is vector-transmitted by female Phlebotomus species through a blood meal. The drugs recommended by the Ministry of Health show moderate efficacy and numerous adverse reactions, making it necessary to develop new drugs. However, it is essential to establish new and vibrant diagnostic techniques detecting and quantifying the parasites in experimental animals...
May 2024
An in vitro evaluation of the antileishmanial and cytotoxic activity of methyl gallate associated with conventional treatment for cutaneous leishmaniasis
Cutaneous leishmaniasis (CL) is a non-contagious infectious-parasitic disease caused by protozoa of the genus Leishmania sp. It is considered a neglected tropical disease and involves public health issues because it affects socially vulnerable populations. The therapy recommended by the Brazilian Ministry of Health as the standard treatment for CL presents numerous challenges. Therefore, it is necessary to look for...
May 2024
Evaluation and validation of limited sampling strategy for estimating individual exposure of mycophenolic acid in renal transplant children receiving concomitant tacrolimus
Limited sampling strategies (LSS) for estimating the area under the concentration-time curve (AUC) of mycophenolic acid (MPA) in renal transplant children receiving concomitant tacrolimus have been developed, but they have not yet undergone full validation. The objectives of the present study were to evaluate the predictive performance of previously published LSS of MPA in an independent pediatric population and to...
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