Abstract

The global prevalence of diabetes mellitus is rising and is predicted to exceed 10% by 2030. Foot ulcers are a frequent complication of diabetes mellitus.  Existing treatments for diabetic foot ulcers are only partially effective and when these ulcers do not heal, amputation of the affected limb may result. It is estimated that an amputation due to diabetic foot infection occurs every 30 seconds somewhere in the world. Thus, more effective treatments are needed. One possible treatment is chlorine dioxide, a chemical compound that shows great promise as a treatment for diabetic foot ulcers. A review of the literature finds multiple mechanisms by which chlorine dioxide and the related compound chlorite may assist in the treatment of diabetic foot ulcers. These include reducing hyperglycemia, decreasing oxidative stress, improving vasculopathy, slowing the progression of neuropathy, decreasing inflammation, treating infection and improving wound healing. Chlorine dioxide and chlorite are found to be safe and effective when used in low doses. Additional research into the potential benefits of chlorine dioxide and chlorite as treatments for diabetic foot ulcers is recommended. 

Key words: Diabetes mellitus, oxidative stress, vasculopathy, neuropathy, infection.